Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany.
Otto von Guericke University, Institute of Experimental Internal Medicine, Medical Faculty, Leipziger Str. 44, 39120 Magdeburg, Germany.
Trends Microbiol. 2017 Apr;25(4):316-328. doi: 10.1016/j.tim.2016.12.004. Epub 2017 Jan 3.
Helicobacter pylori colonizes the gastric mucosa in the human stomach and represents a major risk factor for peptic ulcer disease and gastric cancer. Here, we summarize our current knowledge of the complex impact of H. pylori on manipulating host signalling networks, that is, by the cag pathogenicity island (cagPAI)-encoded type IV secretion system (T4SS). We show that H. pylori infections reflect a paradigm for interspecies contact-dependent molecular communication, which includes the disruption of cell-cell junctions and cytoskeletal rearrangements, as well as proinflammatory, cell cycle-related, proliferative, antiapoptotic, and DNA damage responses. The contribution of these altered signalling cascades to disease outcome is discussed.
幽门螺杆菌定植于人类胃部的胃黏膜，是消化性溃疡病和胃癌的主要危险因素。在这里，我们总结了目前对幽门螺杆菌操纵宿主信号网络的复杂影响的认识，即 cag 致病岛（cagPAI）编码的 IV 型分泌系统（T4SS）。我们表明，幽门螺杆菌感染反映了种间接触依赖性分子通讯的范例，其中包括细胞-细胞连接的破坏和细胞骨架的重排，以及促炎、细胞周期相关、增殖、抗凋亡和 DNA 损伤反应。讨论了这些改变的信号级联反应对疾病结局的贡献。
