Evans Richard P T, Mourad Moustafa Mabrouk, Fisher Simon G, Bramhall Simon R
Richard PT Evans, Moustafa Mabrouk Mourad, Simon G Fisher, Simon R Bramhall, Department of Surgery, the Wye Valley NHS Trust, HR1 2ER Hereford, United Kingdom.
World J Gastroenterol. 2016 Dec 21;22(47):10316-10324. doi: 10.3748/wjg.v22.i47.10316.
Oesophageal cancer affects more than 450000 people worldwide and despite continued medical advancements the incidence of oesophageal cancer is increasing. Oesophageal cancer has a 5 year survival of 15%-25% and now globally attempts are made to more aggressively diagnose and treat Barrett's oesophagus the known precursor to invasive disease. Currently diagnosis the of Barrett's oesophagus is predominantly made after endoscopic visualisation and histopathological confirmation. Minimally invasive techniques are being developed to improve the viability of screening programs. The management of Barrett's oesophagus can vary greatly dependent on the presence and severity of dysplasia. There is no consensus between the major international medical societies to determine and agreed surveillance and intervention pathway. In this review we analysed the current literature to demonstrate the evolving management of metaplasia and dysplasia in Barrett's epithelium.
全球有超过45万人受食管癌影响，尽管医学不断进步，但食管癌的发病率仍在上升。食管癌的5年生存率为15% - 25%，目前全球都在努力更积极地诊断和治疗巴雷特食管，它是侵袭性疾病的已知前驱病变。目前，巴雷特食管的诊断主要在内镜可视化和组织病理学确认之后进行。正在开发微创技术以提高筛查项目的可行性。巴雷特食管的管理方式因发育异常的存在和严重程度而异。主要国际医学协会之间对于确定并商定监测和干预途径尚无共识。在本综述中，我们分析了当前文献，以展示巴雷特上皮化生和发育异常不断演变的管理方式。
