Barbarossa Andrea, Gazzotti Teresa, Farabegoli Federica, Mancini Francesca R, Zironi Elisa, Busani Luca, Pagliuca Giampiero
CABA-Lab, Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna , Ozzano Emilia (BO).
Veterinary Epidemiology and Risk Assessment Unit, Department of Food Safety and Veterinary Public Health, National Institute of Health , Rome, Italy.
Ital J Food Saf. 2016 Nov 2;5(4):6055. doi: 10.4081/ijfs.2016.6055. eCollection 2016 Sep 20.
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are pollutants of anthropic origin with possible side effects on human health. Diet, and in particular fish and seafood, is considered the major intake pathway for humans. The present study investigated the levels of perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) contamination in twenty-five samples of fresh fillet of five widely consumed fish species purchased from large retailers in Italy, to be used for an estimation of the Italian population exposure to these contaminants. PFOS and PFOA were found in all samples, at concentrations up to 1896 (mean=627 ng/kg) and 487 ng/kg (mean = 75 ng/kg), respectively, confirming the role of fish as high contributor to human exposure. However, a remarkable inter-species variability was observed, and multiple factors were suggested as potentially responsible for such differences, suggesting that the preferential consumption of certain species could likely increase the intake, and thus the exposure. The exposure estimates for both average and high fish consumers resulted far below the tolerable daily intakes for PFOS and PFOA in all age groups, confirming the outcomes of EFSA's scientific report. In particular, the calculated total dietary exposure for the 95 percentile consumers belonging to the toddler age class, the most exposed group, resulted equal to 9.72 ng/kg body weight (BW)/day for PFOS and 8.39 ng/kg BW/day for PFOA.
全氟烷基和多氟烷基物质（PFASs）是人为来源的污染物，可能对人类健康产生副作用。饮食，尤其是鱼类和海鲜，被认为是人类摄入这些物质的主要途径。本研究调查了从意大利大型零售商购买的五种广泛消费鱼类的25个新鲜鱼片样本中全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的污染水平，以估算意大利人群对这些污染物的暴露情况。在所有样本中均检测到PFOS和PFOA，其浓度分别高达1896（平均=627纳克/千克）和487纳克/千克（平均=75纳克/千克），证实了鱼类是人类暴露的主要来源。然而，观察到显著的种间差异，并提出多种因素可能是造成这种差异的原因，这表明优先食用某些鱼类可能会增加摄入量，从而增加暴露风险。所有年龄组中，普通和高鱼类消费量人群的暴露估计值均远低于PFOS和PFOA的每日耐受摄入量，这与欧洲食品安全局（EFSA）科学报告的结果一致。特别是，计算得出的属于幼儿年龄组（暴露程度最高的群体）的第95百分位数消费者的总膳食暴露量，PFOS为9.72纳克/千克体重/天，PFOA为8.39纳克/千克体重/天。
