Collak Abdulhamit, Bozaykut Abdulkadir, Demirel Bilge, Sezer Rabia Gonul, Seren Lale Pulat, Dogru Mahmut
Department of Pediatrics, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
Department of Pediatric Allergy and Immunology, Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital, Istanbul, Turkey.
North Clin Istanb. 2014 Aug 3;1(1):13-18. doi: 10.14744/nci.2014.76486. eCollection 2014.
In this study, we aimed to compare vitamin D levels of children with recurrent tonsillopharingitis and healthy controls, and investigate the relationship between sociodemographic characteristics and serum vitamin D levels.
Children with recurrent tonsillopharingitis and healthy controls aged between 2, and 12 years who consulted to the outpatient clinics of Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital from January to October 2012 were included in this study. Serum 25 (OH) vitamin D levels were studied by tandem mass spectroscopy (tandem ms) method. Risk factors which might be associated with vitamin D levels were questioned. Ethical aproval was obtained from the Ethics Committee of Zeynep Kamil Maternity and Children's Diseases Training and Research Hospital and informed consent from the parents of the children.
A total of 147 children; 74 (50.3%) patients and 73 (49.7%) controls were included in our study. Age, gender and demographic characteristics did not differ significantly between the two groups. Vitamin D levels in patients with recurrent tonsillopharingitis and controls were 19.7±8.7 ng/ml and 23.6±9.2 ng/ml, respectively (p<0.01). Although duration of vitamin D usage was shorter in children with recurrent tonsillopharingitis, this difference was not statistically significant (p>0.05).
Vitamin D levels in children with ≥7 recurrent episodes of tonsillophargitis within the preceeding year were significantly lower compared to the control group. We believe that serum vitamin D levels should be checked in children with recurrent tonsillopharingitis and deficiencies should be treated.
在本研究中，我们旨在比较复发性扁桃体咽炎患儿与健康对照者的维生素D水平，并调查社会人口学特征与血清维生素D水平之间的关系。
纳入2012年1月至10月在泽伊内普·卡米尔妇产儿童医院门诊就诊的2至12岁复发性扁桃体咽炎患儿及健康对照者。采用串联质谱法研究血清25(OH)维生素D水平。对可能与维生素D水平相关的危险因素进行了询问。获得了泽伊内普·卡米尔妇产儿童医院伦理委员会的伦理批准，并获得了患儿家长的知情同意。
本研究共纳入147名儿童；74名（50.3%）患者和73名（49.7%）对照者。两组在年龄、性别和人口学特征方面无显著差异。复发性扁桃体咽炎患者和对照者的维生素D水平分别为19.7±8.7 ng/ml和23.6±9.2 ng/ml（p<0.01）。虽然复发性扁桃体咽炎患儿使用维生素D的时间较短，但这种差异无统计学意义（p>0.05）。
与对照组相比，前一年扁桃体咽炎发作≥7次的患儿维生素D水平显著降低。我们认为，对于复发性扁桃体咽炎患儿应检查血清维生素D水平，如有缺乏应进行治疗。
