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一个血栓形成的病例及 PRES(后部可逆性脑病综合征)

A trombosis story and PRES.

作者信息

Kartal Vural, Zara Zeynep, Yilmaz Sema, Ayhan Aylin, Yoruk Asim, Timur Cetin

机构信息

Department of Pediatrics, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.

Department of Pediatric Hematology and Oncology, Istanbul Medeniyet University, Goztepe Training and Research Hospital, Istanbul, Turkey.

出版信息

North Clin Istanb. 2014 Aug 3;1(1):49-52. doi: 10.14744/nci.2014.25744. eCollection 2014.

Abstract

Trombosis is seen in children with acute lymphoblastic leukemia during or after L-asparaginase treatment. Posterior reversible encephalopathy syndrome (PRES) is a complex syndrome characterized with sudden hypertension, headache, nausea, vomiting, alteration in the state of consciousness, vision defect and seizures. The cases related to this syndrome have been reportedly seen after eclampsia, organ transplantation, immunsuppressive treatments, autoimmune diseases and chemotherapy. Vasogenic edema occuring in the brain parencyhma constitues the basic pathophysiology. We present a case who developed seizures during treatment for B-cell acute lymphoblastic leukemia and diagnosed as posterior reversible encephalopathy.

摘要

血栓形成见于接受L-天冬酰胺酶治疗期间或之后的急性淋巴细胞白血病儿童。后部可逆性脑病综合征(PRES)是一种复杂的综合征,其特征为突然高血压、头痛、恶心、呕吐、意识状态改变、视力缺陷和癫痫发作。据报道,该综合征相关病例见于子痫、器官移植、免疫抑制治疗、自身免疫性疾病和化疗之后。脑实质中发生的血管性水肿构成了基本病理生理学。我们报告一例在B细胞急性淋巴细胞白血病治疗期间出现癫痫发作并被诊断为后部可逆性脑病的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e5c8/5175024/135d6a209841/NCI-1-49-g001.jpg

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