稳定型冠状动脉疾病患者的P波离散度及其与疾病严重程度的关系。
P-wave dispersion and its relationship with the severity of the disease in patients with stable coronary artery disease.
作者信息
Akin Fatih, Firatli Inci, Katkat Fahrettin, Gurmen Tevfik, Ayca Burak, Kalyoncuoglu Muhsin, Abaci Okay, Sari Mustafa, Ersanli Murat, Kucukoglu Serdar, Yigit Zerrin
机构信息
Department of Cardiology, Mugla Sitki Kocman University School of Medicine, Mugla, Turkey.
Department of Cardiology, Istanbul University Institute of Cardiology, Istanbul, Turkey.
出版信息
North Clin Istanb. 2014 Dec 8;1(2):65-70. doi: 10.14744/nci.2014.25733. eCollection 2014.
OBJECTIVE
P- wave dispersion (PD) is an indicator of inhomogeneous and discontinuous propagation of sinus impulses. In the present study we aimed to investigate the PD and its association with the severity of the disease. in patients with stable coronary artery disease.
METHODS
We prospectively analyzed 60 subjects with coronary artery disease (CAD) and 25 subjects with nor-mal coronary angiograms (control group). The maximum and minimum P-wave duration and PD were measured from the 12-lead surface electrocardiograms. The CAD severity was assessed by the severity score (Gensini score) and the number of vessels involved (vessel score).
RESULTS
P max was longer in CAD group compared with the control group (p<0.001). PD was greater in the CAD group, compared with the control group (p<0.001). However, P min did not differ between the two groups. In bi-variate correlation, increased PD was correlated with presence of diabetes mellitus (r=0.316, p=0.014), smoking (r=0.348, p=0.006), left ventricular ejection fraction (r=-0.372, p=0.003), vessel score (r=0.848, p=0.001), and Gensini score (r=0.825, p=0.001). Multiple linear regression analysis showed that PD was independently associ¬ated with vessel score ((3=0.139, p=0.002) and Gensini score ((3=0.132, p=0.007).
CONCLUSION
PD was greater in patients with CAD than in controls and it was associated with CAD severity.
目的
P波离散度（PD）是窦性冲动不均匀和不连续传导的一个指标。在本研究中，我们旨在调查稳定性冠心病患者的P波离散度及其与疾病严重程度的关系。
方法
我们前瞻性分析了60例冠心病（CAD）患者和25例冠状动脉造影正常的受试者（对照组）。从12导联体表心电图测量最大和最小P波时限以及P波离散度。通过严重程度评分（Gensini评分）和受累血管数量（血管评分）评估CAD的严重程度。
结果
CAD组的Pmax较对照组更长（p<0.001）。CAD组的P波离散度大于对照组（p<0.001）。然而，两组之间的Pmin没有差异。在双变量相关性分析中，P波离散度增加与糖尿病的存在（r=0.316，p=0.014）、吸烟（r=0.348，p=0.006）、左心室射血分数（r=-0.372，p=0.003）、血管评分（r=0.848，p=0.001）和Gensini评分（r=0.825，p=0.001）相关。多元线性回归分析显示，P波离散度与血管评分（β=0.139，p=0.002）和Gensini评分（β=0.132，p=0.007）独立相关。
结论
CAD患者的P波离散度高于对照组，且与CAD严重程度相关。
Zotero 插件