Kanengiser L C, Rapoport D M, Epstein H, Goldring R M
Department of Medicine, New York University-Bellevue Medical Center, New York.
Chest. 1989 Nov;96(5):1036-42. doi: 10.1378/chest.96.5.1036.
Relationships of lung mechanics and diffusion to lung volume were examined in 38 patients with interstitial lung disease to determine whether patterns of reduction relate to severity of disease, distinguish histologic characteristics or predict prognosis for reversibility. Normal volume-related values for both mechanics and diffusion were seen throughout the range of severity of disease. The ratio of mechanics to lung volume did not correlate with the ratio of diffusion to lung volume in the same patient. Volume relationships of mechanics and diffusion failed to distinguish pathologic predominance of fibrosis or inflammation/granulomas. These ratios failed to predict reversibility in patients who had repeated tests. These results suggest that in patients with interstitial lung disease the significance of "volume-adjustment" of mechanics and diffusion should be viewed with caution; these parameters do not appear to contribute to the assessment of pathophysiology or correlate with clinical spectrum of interstitial lung diseases.
对38例间质性肺疾病患者的肺力学和弥散与肺容积的关系进行了研究，以确定降低模式是否与疾病严重程度相关、区分组织学特征或预测可逆性预后。在整个疾病严重程度范围内均观察到力学和弥散的正常容积相关值。同一患者中，力学与肺容积的比值与弥散与肺容积的比值不相关。力学和弥散的容积关系未能区分纤维化或炎症/肉芽肿的病理优势。这些比值未能预测接受重复检测患者的可逆性。这些结果表明，对于间质性肺疾病患者，应谨慎看待力学和弥散“容积调整”的意义；这些参数似乎无助于评估病理生理学，也与间质性肺疾病的临床谱不相关。
