Okutan Oguzhan, Kartaloglu Zafer, Ilvan Ahmet, Kutlu Ali, Bozkanat Erkan, Silit Emir
GATA Haydarpasa Training Hospital, Department of Pulmonary Diseases, Istanbul, Turkey.
World J Gastroenterol. 2004 Feb 1;10(3):381-4. doi: 10.3748/wjg.v10.i3.381.
To investigate pulmonary involvement via pulmonary function tests (PFT) and high-resolution computed tomography (HRCT) in patients with chronic hepatitis C virus (HCV) infection.
Thirty-four patients with chronic HCV infection without diagnosis of any pulmonary diseases and 10 healthy cases were enrolled in the study. PFT and HRCT were performed in all cases.
A decrease lower than 80% of the predicted value was detected in vital capacity in 9/34 patients, in forced expiratory volume in one second in 8/34 patients, and in forced expiratory flow 25-75 in 15/34 patients, respectively. Carbon monoxide diffusing capacity (DLCO) was decreased in 26/34 patients. Findings of interstitial pulmonary involvement were detected in the HRCT of 16/34 patients. Significant difference was found between controls and patients with HCV infection in findings of HRCT (chi2=4.7, P=0.003). Knodell histological activity index (KHAI) of 28/34 patients in whom liver biopsy was applied was 9.0+/-4.7. HRCT findings, PFT values and DLCO were not affected by KHAI in patients with HCV infection. In these patients, all the parameters were related with age.
We suggest that chronic hepatitis C virus infection may cause pulmonary interstitial involvement without evident respiratory symptoms.
通过肺功能测试（PFT）和高分辨率计算机断层扫描（HRCT）研究慢性丙型肝炎病毒（HCV）感染患者的肺部受累情况。
34例未诊断出任何肺部疾病的慢性HCV感染患者和10例健康对照者纳入本研究。所有病例均进行了PFT和HRCT检查。
34例患者中，分别有9例肺活量、8例一秒用力呼气量、15例25%-75%用力呼气流量低于预测值的80%。34例患者中有26例一氧化碳弥散量（DLCO）降低。34例患者的HRCT检查发现16例有间质性肺受累表现。HCV感染患者与对照组的HRCT表现存在显著差异（χ2=4.7，P=0.003）。34例接受肝活检的患者中，28例的Knodell组织学活动指数（KHAI）为9.0±4.7。HCV感染患者的HRCT表现、PFT值和DLCO不受KHAI影响。在这些患者中，所有参数均与年龄相关。
我们认为慢性丙型肝炎病毒感染可能导致肺部间质性受累而无明显呼吸道症状。
