通过钯催化的串联反应立体选择性合成 3-(1,3-二芳基烯丙基)氧化吲哚。
Stereoselective Synthesis of 3-(1,3-Diarylallylidene)oxindoles via a Palladium-Catalyzed Tandem Reaction.
机构信息
Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea , Bucheon-si, Gyeonggi-do 14662, Korea.
出版信息
J Org Chem. 2017 Feb 3;82(3):1864-1871. doi: 10.1021/acs.joc.6b02909. Epub 2017 Jan 23.
PMID:28058839
Abstract
We have developed an efficient three-component tandem reaction for the synthesis of 3-(1,3-diarylallylidene)oxindoles combining three palladium-catalyzed reactions: the Sonogashira, Heck, and Suzuki-Miyaura reactions. This method allows a stereoselective approach to each (E)- and (Z)-isomer by ligand change and controlling the reaction temperature.
摘要
我们开发了一种有效的三组分串联反应，用于合成 3-(1,3-二芳基烯丙基)氧化吲哚，结合了三个钯催化反应：Sonogashira、Heck 和 Suzuki-Miyaura 反应。通过配体变化和控制反应温度，该方法可以对每种 (E)-和 (Z)-异构体进行立体选择性合成。
Zotero 插件