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1955年至1984年斯德哥尔摩县溃疡性结肠炎的外科治疗

Surgical treatment of ulcerative colitis in Stockholm County, 1955 to 1984.

作者信息

Leijonmarck C E, Broström O, Monsen U, Hellers G

机构信息

Department of Surgery, St. Göran's Hospital, Stockholm, Sweden.

出版信息

Dis Colon Rectum. 1989 Nov;32(11):918-26. doi: 10.1007/BF02552266.

Abstract

Time trends in surgical treatment of ulcerative colitis in Stockholm County over the 30-year period 1955 to 1984 were investigated. Four hundred eighty-six patients (263 men and 223 women) were submitted to colectomy with or without proctectomy. In elective cases, proctocolectomy was the procedure of choice until the 1980s, when subtotal colectomy became more common. In acute cases subtotal colectomy was the procedure of choice during the entire period. Major complications developed in 162 patients (33 percent) and 103 (21 percent) underwent another operation. The frequency of major complications increased, with the urgency of intervention being 25 percent in elective cases and 46 percent in acute cases (P less than .001). The postoperative mortality was 1.7 percent in 301 elective cases and 9.2 percent in 185 acute cases (P less than .001). The overall postoperative mortality was 4.5 percent and fell from 13 percent during 1960 to 1964 to 2.0 percent during 1980 to 1984 (P less than .01). In acute cases, the mortality during the same two periods fell from 36 to 3.0 percent (P less than .001). The postoperative mortality for proctocolectomy (2.7 percent) was significantly lower (P less than .01) than for subtotal colectomy (9.0 percent). Seventy-four percent of the patients treated by subtotal colectomy were acute cases, however, with a mortality of 11 percent and only 30 percent of the proctocolectomy cases were acute cases, with a mortality of 6.5 percent.

摘要

对1955年至1984年这30年间斯德哥尔摩县溃疡性结肠炎外科治疗的时间趋势进行了调查。486例患者(263名男性和223名女性)接受了结肠切除术,部分患者还接受了直肠切除术。在择期手术中,直到20世纪80年代,全结肠直肠切除术一直是首选术式,此后次全结肠切除术更为常见。在急症手术中,次全结肠切除术在整个时期都是首选术式。162例患者(33%)出现了严重并发症,103例(21%)接受了再次手术。严重并发症的发生率有所增加,择期手术中紧急干预的发生率为25%,急症手术中为46%(P<0.001)。301例择期手术的术后死亡率为1.7%,185例急症手术的术后死亡率为9.2%(P<0.001)。总体术后死亡率为4.5%,从1960年至1964年的13%降至1980年至1984年的2.0%(P<0.01)。在急症手术中,同一两个时期的死亡率从36%降至3.0%(P<0.001)。全结肠直肠切除术的术后死亡率(2.7%)显著低于次全结肠切除术(9.0%)(P<0.01)。然而,接受次全结肠切除术的患者中有74%为急症手术,死亡率为11%,而接受全结肠直肠切除术的患者中只有30%为急症手术,死亡率为6.5%。

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