Fuenzalida Loreto, García-Díaz Diego F
Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Santiago, Chile.
Departamento de Nutrición, Facultad de Medicina, Universidad de Chile, Santiago, Chile,
Rev Med Chil. 2016 Sep;144(9):1177-1184. doi: 10.4067/S0034-98872016000900012.
Obesity has a high prevalence among children. On the other hand, acute respiratory infections especially of viral origin, are an important cause of morbidity and mortality in this age group. During the recent pandemic of influenza A (H1N1) virus, obesity was identified as a novel independent risk factor for severity multiple markers of the disease. We reviewed the evidence associating obesity with a worse course of respiratory diseases in children. Nine out of 40 retrieved articles, were chosen to be reviewed. We concluded that there is evidence suggesting that immunomodulatory effects of obesity could be considered as a novel risk factor. Thus, bearing in mind the drastic rise in obesity prevalence around the world and in Chile, and the latent possibility of new respiratory pandemics caused by viruses, studying the possible effect of obesity aggravating viral respiratory infections will become important.
肥胖在儿童中具有很高的患病率。另一方面，急性呼吸道感染，尤其是病毒源性感染，是该年龄组发病和死亡的重要原因。在最近的甲型H1N1流感病毒大流行期间，肥胖被确定为该疾病严重程度多种标志物的一个新的独立危险因素。我们回顾了将肥胖与儿童呼吸道疾病病情加重相关联的证据。从检索到的40篇文章中选出9篇进行综述。我们得出结论，有证据表明肥胖的免疫调节作用可被视为一个新的危险因素。因此，鉴于全球及智利肥胖患病率的急剧上升，以及由病毒引发新的呼吸道大流行的潜在可能性，研究肥胖加重病毒性呼吸道感染的可能影响将变得至关重要。
