[金刚烷胺中毒和缺氧后血浆中的促红细胞生成素活性]

[Erythropoietin activity in plasma after amantinine poisoning and hypoxia].

作者信息

Nikolov V, Logofetov A, Kalaĭdzhieva V

出版信息

Eksp Med Morfol. 1989;28(3):38-42.

Abstract

Determination of plasma erythropoietin activity was performed on highly sensitive to exogenous erythropoietin recipients-posthypoxic polycytemic mice. After submitting male white rats to a two-hour hypobaric hypoxia (0.42 atm.) we obtained an increase in the plasma erythropoietic activity with 367% in comparison with control animals. Amanitin effect inhibited hypoxic stimulated plasma erythropoietin activity in male rabbits of the strain Chinchilla, which was statistically significant (p less than 0.01), but 4 hours after its application erythropoietin level was lowered with 68% in rabbits with a preceding hypoxia and intraperitoneal administration of Amanitin in comparison with nontreated hypoxic animals. The results were similar 48 hours after amanitin application as well. The results suggest that intraperitoneal administration of Amanita faloides before the onset of hypoxia diminishes erythropoietin production.

摘要

对对外源性促红细胞生成素高度敏感的受体——低氧后红细胞增多症小鼠进行血浆促红细胞生成素活性测定。将雄性白鼠置于两小时的低压低氧环境（0.42个大气压）后，与对照动物相比，我们发现其血浆促红细胞生成活性增加了367%。鹅膏菌素的作用抑制了青紫蓝兔品系雄性兔子低氧刺激的血浆促红细胞生成素活性，这具有统计学意义（p小于0.01），但在应用鹅膏菌素4小时后，与未处理的低氧动物相比，先前低氧且腹腔注射鹅膏菌素的兔子促红细胞生成素水平降低了68%。在应用鹅膏菌素48小时后结果同样如此。结果表明，在低氧开始前腹腔注射毒蝇伞可减少促红细胞生成素的产生。