• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

扁平苔藓区域的阴蒂疣状癌具有侵袭性特征。

A clitoral verrucous carcinoma in an area of lichen planus has aggressive features.

作者信息

Tjalma Wiebren A A, Siozopoulou Vasiliki, Huizing Manon T

机构信息

Department of Obstetrics and Gynecology, Multidisciplinary Breast Clinic, Gynecological Oncology Unit, Antwerp University Hospital - University of Antwerp, Wilrijkstraat 10, Edegem, 2650, Belgium.

出版信息

World J Surg Oncol. 2017 Jan 6;15(1):7. doi: 10.1186/s12957-016-1069-0.

DOI:10.1186/s12957-016-1069-0
PMID:28061900
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5217222/
Abstract

BACKGROUND

Verrucous carcinoma of the vulva is extremely rare. It is a slow growing, low malignant variant of a squamous cell carcinoma with a cauliflower appearance. Women with lichen planus have an increased risk of developing vulval cancer.

CASE PRESENTATION

A 79-year-old woman consulted for vulval itching. On clinical examination, a 3-cm large verrucous clitoral cancer in an area of lichen planus was seen. Based on her last clinical examination, the growth was estimated to be 1 cm per month with an invasion depth after 6 months of 5 mm. A tumor developing in an area of lichen planus appears to have more aggressive features. This is the first time that the growth of a verrucous carcinoma has been documented in an area of lichen planus.

CONCLUSIONS

Clinicians and patients should be aware of the aggressive behavior of cancers developing in areas of lichen planus and adjust their surgical management together with the follow-up strategy.

摘要

背景

外阴疣状癌极为罕见。它是鳞状细胞癌的一种生长缓慢、低恶性的变体，外观呈菜花状。扁平苔藓女性患外阴癌的风险增加。

病例介绍

一名79岁女性因外阴瘙痒前来就诊。临床检查发现，在扁平苔藓区域有一个3厘米大的疣状阴蒂癌。根据她上次的临床检查，肿瘤生长速度估计为每月1厘米，6个月后浸润深度为5毫米。在扁平苔藓区域发生的肿瘤似乎具有更具侵袭性的特征。这是首次记录到疣状癌在扁平苔藓区域的生长情况。

结论

临床医生和患者应意识到在扁平苔藓区域发生的癌症具有侵袭性，并共同调整手术治疗及随访策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/a06e7934e3db/12957_2016_1069_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/63c59d26a2c8/12957_2016_1069_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/f7fee2b18f7a/12957_2016_1069_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/b74b11e0ec33/12957_2016_1069_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/8d298e23ad41/12957_2016_1069_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/2f92186fb260/12957_2016_1069_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/a06e7934e3db/12957_2016_1069_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/63c59d26a2c8/12957_2016_1069_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/f7fee2b18f7a/12957_2016_1069_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/b74b11e0ec33/12957_2016_1069_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/8d298e23ad41/12957_2016_1069_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/2f92186fb260/12957_2016_1069_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7c09/5217222/a06e7934e3db/12957_2016_1069_Fig6_HTML.jpg

相似文献

1
A clitoral verrucous carcinoma in an area of lichen planus has aggressive features.扁平苔藓区域的阴蒂疣状癌具有侵袭性特征。
World J Surg Oncol. 2017 Jan 6;15(1):7. doi: 10.1186/s12957-016-1069-0.
2
Squamous carcinoma following lichen planus of the vulva.外阴扁平苔藓继发鳞状细胞癌。
Clin Exp Dermatol. 1995 Mar;20(2):171-2. doi: 10.1111/j.1365-2230.1995.tb02677.x.
3
[Verrucous squamous cell carcinoma developing in hypertrophic lichen planus].[肥厚性扁平苔藓中发生的疣状鳞状细胞癌]
Hautarzt. 2004 Apr;55(4):385-7. doi: 10.1007/s00105-004-0712-9.
4
[Verrucous carcinoma of the tongue occurring on lesions of lichen planus].[发生于扁平苔藓病变上的舌疣状癌]
Ann Dermatol Venereol. 2003 Jan;130(1 Pt 1):55-7.
5
Vulval lichen planus.外阴扁平苔藓
Br J Dermatol. 1998 Apr;138(4):569-75. doi: 10.1046/j.1365-2133.1998.02164.x.
6
[Verrucous carcinoma of the penis arising from a lichen planus. A true preneoplastic lesion?].[阴茎扁平苔藓引发的疣状癌。一种真正的癌前病变？]
Actas Urol Esp. 2006 Jan;30(1):90-2. doi: 10.4321/s0210-48062006000100015.
7
Verrucous carcinoma in association with hypertrophic lichen planus.疣状癌合并肥厚性扁平苔藓。
Clin Exp Dermatol. 1997 Jan;22(1):23-5. doi: 10.1046/j.1365-2230.1997.d01-241.x.
8
Mucosal vulval lichen planus: outcome, clinical and laboratory features.黏膜性外阴扁平苔藓：结局、临床及实验室特征
J Eur Acad Dermatol Venereol. 2005 May;19(3):301-7. doi: 10.1111/j.1468-3083.2004.01167.x.
9
Squamous cell carcinoma arising in vulval lichen planus.外阴扁平苔藓中发生的鳞状细胞癌。
Br J Dermatol. 1994 Nov;131(5):703-5. doi: 10.1111/j.1365-2133.1994.tb04987.x.
10
'Primary gingival and later primary vulval carcinomas arising in lichen planus: report of a case and clinical suggestions for diagnosis of a neglected disease'.“发生于扁平苔藓的原发性牙龈和随后原发性外阴癌：一例报告及对一种被忽视疾病的诊断的临床建议”。
Gynecol Endocrinol. 2019 Nov;35(11):938-940. doi: 10.1080/09513590.2019.1617265. Epub 2019 May 26.

引用本文的文献

1
Mycosis fungoides of the vulva.外阴蕈样肉芽肿
North Clin Istanb. 2020 Nov 23;8(1):101-105. doi: 10.14744/nci.2020.12129. eCollection 2021.
2
Verrucous Carcinoma of the Vulva: A Case Report and Literature Review.外阴疣状癌：一例报告及文献综述
Am J Case Rep. 2019 Apr 19;20:551-556. doi: 10.12659/AJCR.914367.

本文引用的文献

1
Update on lichen planus and its clinical variants.扁平苔藓及其临床变体的最新进展。
Int J Womens Dermatol. 2015 Sep 16;1(3):140-149. doi: 10.1016/j.ijwd.2015.04.001. eCollection 2015 Aug.
2
Cancer statistics, 2015.癌症统计数据，2015 年。
CA Cancer J Clin. 2015 Jan-Feb;65(1):5-29. doi: 10.3322/caac.21254. Epub 2015 Jan 5.
3
Vulvar cancers in women with vulvar lichen planus: a clinicopathological study.外阴扁平苔藓患者的外阴癌：一项临床病理研究。
J Am Acad Dermatol. 2014 Oct;71(4):698-707. doi: 10.1016/j.jaad.2014.05.057. Epub 2014 Jul 4.
4
Two major pathways of penile carcinogenesis: HPV-induced penile cancers overexpress p16ink4a, HPV-negative cancers associated with dermatoses express p53, but lack p16ink4a overexpression.阴茎癌发生的两个主要途径：HPV 诱导的阴茎癌过度表达 p16ink4a，与皮肤病相关的 HPV 阴性癌症表达 p53，但缺乏 p16ink4a 的过度表达。
J Am Acad Dermatol. 2013 Jul;69(1):73-81. doi: 10.1016/j.jaad.2012.12.973. Epub 2013 Mar 6.
5
Verrucous carcinoma of the vulva: a case report.外阴疣状癌：一例报告
Case Rep Obstet Gynecol. 2013;2013:932712. doi: 10.1155/2013/932712. Epub 2013 Jan 16.
6
Management of vulvovaginal lichen planus: a new approach.外阴阴道扁平苔藓的治疗：新方法。
J Low Genit Tract Dis. 2013 Jan;17(1):28-32. doi: 10.1097/LGT.0b013e318258bf5b.
7
Penile carcinogenesis in a low-incidence area: a clinicopathologic and molecular analysis of 115 invasive carcinomas with special emphasis on chronic inflammatory skin diseases.低发地区的阴茎癌发生：115 例浸润性癌的临床病理和分子分析，特别强调慢性炎症性皮肤病。
Am J Surg Pathol. 2011 Jul;35(7):998-1006. doi: 10.1097/PAS.0b013e3182147e59.
8
Anogenital malignancies and pre-malignancies.肛门生殖器恶性肿瘤及癌前病变。
J Eur Acad Dermatol Venereol. 2011 Aug;25(8):885-95. doi: 10.1111/j.1468-3083.2010.03969.x. Epub 2011 Jan 28.
9
The rapid development of a giant condyloma acuminatum (Buschke-Löwenstein tumor) during pregnancy.妊娠期巨大尖锐湿疣（Buschke-Löwenstein瘤）的快速发展。
Acta Obstet Gynecol Scand. 2007;86(6):762-3. doi: 10.1080/00016340600617999.
10
Verrucous carcinoma of the vulva in Turner syndrome.
Gynecol Oncol. 2004 Jan;92(1):380-3. doi: 10.1016/j.ygyno.2003.10.009.