Castaño E, López-Ríos F, Alvarez-Fernández J G, Rodríguez-Peralto J L, Iglesias L
Department of Dermatology, Hospital 12 de Octubre, Madrid, Spain.
Clin Exp Dermatol. 1997 Jan;22(1):23-5. doi: 10.1046/j.1365-2230.1997.d01-241.x.
Neoplastic transformation of lichen planus is a rare event. However, squamous cell carcinoma may develop in 0.3%-3% of patients with the oral form of the disease. On the other hand, less than 30 cases arising in cutaneous lichen planus have been reported, and only four cases of verrucous carcinoma in association with either form, one with an oral lesion and three with cutaneous lesions (one hypertrophic and one ulcerative). This report describes the unusual progression of a hypertrophic lichen planus plaque of the right leg to a verrucous carcinoma in a 40-year-old woman.
扁平苔藓的肿瘤性转化是一种罕见事件。然而，口腔型扁平苔藓患者中有0.3% - 3%可能发生鳞状细胞癌。另一方面，皮肤扁平苔藓发生癌变的报道少于30例，与任何一种类型相关的疣状癌仅4例，其中1例为口腔病变，3例为皮肤病变（1例肥厚性和1例溃疡性）。本报告描述了一名40岁女性右下肢肥厚性扁平苔藓斑块异常进展为疣状癌的情况。
