Yudin Mark H, Mistry Niraj, De Souza Leanne R, Besel Kate, Patel Vishal, Blanco Mejia Sonia, Bernick Robyn, Ryan Victoria, Urquia Marcelo, Beigi Richard H, Moniz Michelle H, Sgro Michael
Departments of Obstetrics and Gynecology, St. Michael's Hospital, 30 Bond Street, Toronto M5B 1G3, Canada; University of Toronto, Toronto, Ontario, Canada.
Departments of Pediatrics, St. Michael's Hospital, 30 Bond Street, Toronto M5B 1G3, Canada; University of Toronto, Toronto, Ontario, Canada.
Vaccine. 2017 Feb 1;35(5):842-848. doi: 10.1016/j.vaccine.2016.12.002. Epub 2017 Jan 3.
To evaluate if text message reminders increase the likelihood of receiving the influenza vaccine among pregnant women.
Pregnant women were randomized to either receive or not receive weekly text messages. Women were told the messages would be about health-related behavior in pregnancy. Those randomized to the intervention group received two messages weekly for four consecutive weeks reinforcing that the influenza vaccine is recommended for all pregnant women and safe during pregnancy and breastfeeding. Women were contacted six weeks postpartum to determine if they had received the vaccine. Sample size calculation determined that 108 women were required in both groups to see a 75% increase in vaccination rates over baseline in the text message group compared to the control group.
Recruitment began November 4, 2013, and 317 women were randomized. The mean gestational age at recruitment was 22weeks. There were 40/129 (31%) women in the text message group and 41/152 (27%) women in the control group who received the vaccine (p=0.51). Significant predictors of vaccine acceptance were being married compared to single (95% vs. 67%, p<0.001), having higher household income (55% vs. 39%, p=0.03) and having received the vaccine before (77% vs. 36%, p<0.001). Among women receiving text messages, the majority were satisfied, with only 15/129 (12%) reporting that they did not like receiving the messages, and 24/129 (19%) stating that the information in the messages was not helpful.
Weekly text messages reinforcing the recommendation for and safety of the influenza vaccine in pregnancy did not increase the likelihood of actually receiving the vaccine among pregnant women. Overall vaccination rates were low, highlighting the need for patient education and innovative techniques to improve vaccine acceptance. Registered with ClinicalTrials.gov at http://www.clinicaltrials.gov, registration number NCT 02428738.
评估短信提醒是否会增加孕妇接种流感疫苗的可能性。
将孕妇随机分为两组，一组接收每周的短信，另一组不接收。告知女性这些短信将与孕期健康相关行为有关。随机分配到干预组的女性连续四周每周收到两条短信，强调所有孕妇都建议接种流感疫苗，且在孕期和哺乳期接种是安全的。在产后六周联系这些女性，以确定她们是否接种了疫苗。样本量计算表明，两组各需要108名女性，以便与对照组相比，短信组的接种率比基线提高75%。
招募工作于2013年11月4日开始，共有317名女性被随机分组。招募时的平均孕周为22周。短信组中有40/129（31%）的女性接种了疫苗，对照组中有41/152（27%）的女性接种了疫苗（p = 0.51）。疫苗接受情况的显著预测因素包括已婚（95%对67%，p < 0.001）、家庭收入较高（55%对39%，p = 0.03）以及之前接种过疫苗（77%对36%，p < 0.001）。在接收短信的女性中，大多数人感到满意，只有15/129（12%）的人表示不喜欢收到短信，24/129（19%）的人表示短信中的信息没有帮助。
每周发送短信强化孕期接种流感疫苗的建议及其安全性，并未增加孕妇实际接种疫苗的可能性。总体接种率较低，凸显了患者教育和创新技术对于提高疫苗接受度的必要性。在http://www.clinicaltrials.gov上注册于ClinicalTrials.gov，注册号为NCT 02428738。
