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开展皮肤微生物组研究:混乱中的方法。

Performing Skin Microbiome Research: A Method to the Madness.

作者信息

Kong Heidi H, Andersson Björn, Clavel Thomas, Common John E, Jackson Scott A, Olson Nathan D, Segre Julia A, Traidl-Hoffmann Claudia

机构信息

Dermatology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland, USA.

Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.

出版信息

J Invest Dermatol. 2017 Mar;137(3):561-568. doi: 10.1016/j.jid.2016.10.033. Epub 2017 Jan 4.

Abstract

Growing interest in microbial contributions to human health and disease has increasingly led investigators to examine the microbiome in both healthy skin and cutaneous disorders, including acne, psoriasis, and atopic dermatitis. The need for common language, effective study design, and validated methods is critical for high-quality standardized research. Features, unique to skin, pose particular challenges when conducting microbiome research. This review discusses microbiome research standards and highlights important factors to consider, including clinical study design, skin sampling, sample processing, DNA sequencing, control inclusion, and data analysis.

摘要

人们对微生物对人类健康和疾病的作用越来越感兴趣,这促使研究人员越来越多地研究健康皮肤和皮肤疾病(包括痤疮、牛皮癣和特应性皮炎)中的微生物群。对于高质量的标准化研究而言,使用通用语言、进行有效的研究设计以及采用经过验证的方法至关重要。在开展微生物群研究时,皮肤特有的特征带来了特殊挑战。本综述讨论了微生物群研究标准,并强调了需要考虑的重要因素,包括临床研究设计、皮肤采样、样本处理、DNA测序、纳入对照以及数据分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0d32/5468751/56a60142e706/nihms865411f1.jpg

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