雷帕霉素哺乳动物靶点在雄性生育中的新作用。
Emerging Role for Mammalian Target of Rapamycin in Male Fertility.
作者信息
Oliveira Pedro F, Cheng C Y, Alves Marco G
机构信息
Department of Microscopy, Laboratory of Cell Biology, Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; Unit for Multidisciplinary Research in Biomedicine (UMIB), Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto, Porto, Portugal; Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Population Council's Center for Biomedical Research, New York, USA.
出版信息
Trends Endocrinol Metab. 2017 Mar;28(3):165-167. doi: 10.1016/j.tem.2016.12.004. Epub 2017 Jan 5.
Male fertility is modulated by environmental, endocrine, paracrine, and metabolic cues. Mammalian target of rapamycin (mTOR) coordinates many cellular events in response to those signals. Here, we discuss how the mTOR pathway integrates and mediates signals throughout the male reproductive system, acting as a central player in the control of spermatogenesis.
男性生育能力受环境、内分泌、旁分泌和代谢信号的调节。雷帕霉素的哺乳动物靶标（mTOR）可协调许多细胞事件以响应这些信号。在此，我们讨论mTOR信号通路如何在整个男性生殖系统中整合和介导信号，在精子发生的控制中发挥核心作用。
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