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构建视觉系统:共同与不同的机制及原理

Wiring visual systems: common and divergent mechanisms and principles.

作者信息

Kolodkin Alex L, Hiesinger P Robin

机构信息

The Solomon H. Snyder Department of Neuroscience and Howard Hughes Medical Institute, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Division of Neurobiology of the Institute for Biology, Free University Berlin, Germany.

出版信息

Curr Opin Neurobiol. 2017 Feb;42:128-135. doi: 10.1016/j.conb.2016.12.006. Epub 2017 Jan 5.

Abstract

The study of visual systems has a rich history, leading to the discovery and understanding of basic principles underlying the elaboration of neuronal connectivity. Recent work in model organisms such as fly, fish and mouse has yielded a wealth of new insights into visual system wiring. Here, we consider how axonal and dendritic patterning in columns and laminae influence synaptic partner selection in these model organisms. We highlight similarities and differences among disparate visual systems with the goal of identifying common and divergent principles for visual system wiring.

摘要

视觉系统的研究有着丰富的历史,这促使人们发现并理解了神经元连接形成的基本原理。近期在果蝇、鱼类和小鼠等模式生物上开展的研究,为视觉系统的布线带来了诸多新见解。在此,我们探讨柱层和板层中的轴突与树突模式如何影响这些模式生物中的突触伙伴选择。我们着重强调不同视觉系统之间的异同,目的是找出视觉系统布线的共同和不同原则。

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