Chernysheva G A, Plotnikov M B, Kastron V V, Vitolinia R O, Dubur G Ia
Farmakol Toksikol. 1989 Jul-Aug;52(4):20-4.
In experiments on anesthetized cats, foridone (1 and 3 micrograms/kg/min intravenously) was found to increase cerebral blood flow by 6-26% with a moderate decrease of systemic arterial blood pressure indicating that the drug possessed properties with respect to a selective cerebral vasodilatator. Phenygidine (0.3-3 micrograms/kg/min) did not exhibit such a property. Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption.
在对麻醉猫进行的实验中，发现福利多酮（静脉注射剂量为1和3微克/千克/分钟）可使脑血流量增加6% - 26%，同时全身动脉血压有适度下降，这表明该药物具有选择性脑血管扩张剂的特性。苯乙胍（0.3 - 3微克/千克/分钟）则未表现出这种特性。脑出血一天后的猫静脉注射福利多酮（1微克/千克/分钟），可使脑供血、脑葡萄糖利用显著改善，氧耗适度增加。
