Plotnikov M B, Korobova Z V, Chernysheva G A
Farmakol Toksikol. 1984 Nov-Dec;47(6):36-9.
It was shown in experiments on conscious cats 1-2 days after intracerebral hemorrhage (administration of 2 ml autogenous blood in the internal capsule of the right hemisphere) that intravenous injection of 50 mg/kg gutimin led to an increase in the brain blood supply. The increased local blood flow was recorded in the cortex, thalamus of the affected hemisphere, particularly in the midbrain reticular formation. Experiments in vitro demonstrated that gutimin had a direct dilatatory action on isolated strips of the cat internal maxillary artery, with this action being determined by inhibition of the metabolism of exo- and intracellular calcium.
在脑出血（向右侧大脑半球内囊注射2ml自体血液）后1-2天对清醒猫进行的实验表明，静脉注射50mg/kg谷胱甘肽可导致脑血流量增加。在受影响半球的皮质、丘脑，特别是中脑网状结构中记录到局部血流增加。体外实验表明，谷胱甘肽对猫上颌内动脉的离体条带具有直接舒张作用，这种作用是由细胞外和细胞内钙代谢的抑制所决定的。
