Stanislavchuk N A, Pentiuk A A, Gorshkov V K, Pentiuk N A
Vopr Med Khim. 1995 Sep-Oct;41(5):42-5.
Riboflavin deficiency decreases the activity of rat hepatic microsomal enzymes, addition of riboflavin and flavin mononucleotide stimulates their activity. At the same time thiamine deficiency induces xenobiotic metabolic enzymes and excessive addition of thiamine, thiamine diphosphate in particular, suppresses their activity. Flavin mononucleotide and thiamine diphosphate considerably modify the pharmacological effect of the agents which are actively metabolized by the hepatic microsomal system. Thiamine diphosphate enhances the pharmacological activities of orthophen, indomethacin, and tramal while flavin mononucleotide slightly diminishes them.
核黄素缺乏会降低大鼠肝脏微粒体酶的活性，添加核黄素和黄素单核苷酸会刺激其活性。同时，硫胺素缺乏会诱导外源性生物代谢酶，而过量添加硫胺素，尤其是硫胺素二磷酸，则会抑制其活性。黄素单核苷酸和硫胺素二磷酸会显著改变由肝脏微粒体系统进行活性代谢的药物的药理作用。硫胺素二磷酸会增强邻苯二酚、吲哚美辛和曲马多的药理活性，而黄素单核苷酸则会使其略有减弱。
