Galley J, Maestretti G, Koch G, Hoogewoud H-M
Department of Radiology, HFR Fribourg, Hôpital Cantonal, Switzerland.
Department of Orthopedic Surgery, HFR Fribourg, Hôpital Cantonal, Switzerland.
Eur J Radiol. 2017 Feb;87:13-19. doi: 10.1016/j.ejrad.2016.12.001. Epub 2016 Dec 6.
To measure the real T1 relaxation time of the lumbar intervertebral discs in a young and healthy population, using different inversion recovery times, and assess diurnal variation.
Intervertebral discs from D12 to S1 of 50 healthy volunteers from 18 to 25 years old were evaluated twice the same day, in the morning and in the late afternoon. Dedicated MRI sequences with different inversion recovery times (from 100 to 2500ms) were used to calculate the real T1 relaxation time. Three regions of interest (ROIs) were defined in each disc, the middle representing the nucleus pulposus (NP) and the outer parts the annulus fibrosus (AF) anterior and posterior. Diurnal variation and differences between each disc level were analyzed.
T1 mean values in the NP were 1142±12ms in the morning and 1085±13ms in the afternoon, showing a highly significant decrease of 57ms (p<0.001). A highly significant difference between the levels of the spine was found. The mean T1 of the anterior part of the AF was 577±9ms in the morning and 554±8ms in the afternoon. For the posterior part, the mean values were 633±8ms in the morning and 581±7ms in the evening. It shows a highly significant decrease of 23ms for the anterior part and 51ms for the posterior part (all p<0.001).
T1 mapping is a promising method of intervertebral disc evaluation. Significant diurnal variation and difference between levels of the lumbar spine were demonstrated. A potential use for longitudinal study in post-operative follow up or sport medicine needs to be evaluated.
使用不同的反转恢复时间测量年轻健康人群腰椎间盘的真实T1弛豫时间，并评估昼夜变化。
对50名年龄在18至25岁的健康志愿者的D12至S1椎间盘在同一天的上午和下午进行两次评估。使用具有不同反转恢复时间（从100至2500毫秒）的专用MRI序列来计算真实T1弛豫时间。在每个椎间盘中定义三个感兴趣区域（ROI），中间代表髓核（NP），外部部分代表前侧和后侧纤维环（AF）。分析昼夜变化以及每个椎间盘水平之间的差异。
NP的T1平均值上午为1142±12毫秒，下午为1085±13毫秒，显示出57毫秒的高度显著下降（p<0.001）。发现脊柱各水平之间存在高度显著差异。AF前侧部分的平均T1上午为577±9毫秒，下午为554±8毫秒。后侧部分的平均值上午为633±8毫秒，晚上为581±7毫秒。前侧部分显示出23毫秒的高度显著下降，后侧部分为51毫秒（所有p<0.001）。
T1映射是一种有前景的椎间盘评估方法。证实了腰椎水平之间存在显著的昼夜变化和差异。需要评估其在术后随访或运动医学纵向研究中的潜在用途。
