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[胆碱能物质对延髓呼吸神经元活动影响的微离子电泳研究]

[Microiontophoretic study of the effect of cholinergic substances on the activity of medullary respiratory neurons].

作者信息

Nersesian L B, Baklavadzhian O G

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1989 Jul;75(7):948-54.

PMID:2806671
Abstract

The responses of single inspiratory, expiratory and unspecific neurons of the medulla oblongata to microelectrophoretic applications of acetylcholine, M- and N-cholinergic-blocking agents (atropine and etpenal) were studied in anesthetized cats. A relatively small amount of cholinoreactive neurons was found. Cholinoreactive units prevailed in the group of unspecific neurons. Electrophoretic application of acetylcholine evoked mainly excitatory responses. A rather mild inhibitory action of anticholinergic drugs on neurons of bulbar respiratory centre was revealed. These reactions seem to be unspecific being evoked in acetylcholine-sensitive and nonsensitive neurons.

摘要

在麻醉猫身上研究了延髓单个吸气、呼气和非特异性神经元对乙酰胆碱、M 型和 N 型胆碱能阻断剂(阿托品和依酚氯铵)微电泳应用的反应。发现胆碱反应性神经元数量相对较少。胆碱反应性单位在非特异性神经元组中占优势。乙酰胆碱的电泳应用主要引起兴奋反应。揭示了抗胆碱能药物对延髓呼吸中枢神经元有相当轻微的抑制作用。这些反应似乎是非特异性的,在对乙酰胆碱敏感和不敏感的神经元中均可诱发。

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Fiziol Zh SSSR Im I M Sechenova. 1989 Jul;75(7):948-54.
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