Nersesian L B, Baklavadzhian O G, Oleĭnik G N, Sarukhanian R V
Fiziol Zh SSSR Im I M Sechenova. 1984 Feb;70(2):130-7.
Morphine, codeine and serotonin (5-HT) were microelectrophoretically applied to inspiratory, expiratory and unspecific reticular neurons located in the region of the bulbar respiratory center in anesthetized cats. Opiate agonists exerted distinct inhibitory effects on inspiratory, expiratory and inspecific neurons. With 5-HT inhibition prevailed in all three types of neurons. The inhibitory effects of GABA were more profound and prolonged in comparison with the depressing effects of opiate agonists and 5-HT. The latters depressed peak frequency of each rhythmic burst of respiratory neurons, while GABA abolished the rhythmic activity. The existence of specific opiate and 5-HT receptors in neurons of the bulbar respiratory center region is discussed.
在麻醉猫的延髓呼吸中枢区域，将吗啡、可待因和5-羟色胺（5-HT）微电泳施加于吸气、呼气和非特异性网状神经元。阿片类激动剂对吸气、呼气和非特异性神经元产生明显的抑制作用。5-HT对所有三种类型的神经元均产生抑制作用。与阿片类激动剂和5-HT的抑制作用相比，γ-氨基丁酸（GABA）的抑制作用更显著且持续时间更长。后两者降低呼吸神经元每个节律性爆发的峰值频率，而GABA则消除节律性活动。文中讨论了延髓呼吸中枢区域神经元中特异性阿片和5-HT受体的存在情况。
