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自体膜诱导软骨形成术(AMIC)治疗髋臼软骨缺损

Autologous Membrane Induced Chondrogenesis (AMIC) for the treatment of acetabular chondral defect.

作者信息

Fontana Andrea

机构信息

Orthopaedic Unit, COF Lanzo Hospital, Ramponio Verna (CO), Italy.

出版信息

Muscles Ligaments Tendons J. 2016 Dec 21;6(3):367-371. doi: 10.11138/mltj/2016.6.3.367. eCollection 2016 Jul-Sep.

DOI:10.11138/mltj/2016.6.3.367
PMID:28066742
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5193527/
Abstract

BACKGROUND

Acetabular chondral defect are very frequently associated to FAI. Treatment options are still questionable.

METHODS

Between 2008 and 2014, 201 patients over 583 have been arthroscopically treated with the AMIC procedure for grade III and/or IV acetabular chondral lesions. Patients age was between 18 and 50 years; acetabular chondral lesion size was between 2 and 4 cm; radiological Tönnis degree of osteoarthritis was ≤ 2.

RESULTS

The mean follow up of the entire group of 201 patients was 5 years (from 8 to 2). Significant improvement, as measured by the mHHS, was observed at 6 months in comparison to preoperative levels (80.3 ± 8.3) (p<0.001). Continuous improvement with respect to each previous evaluation time point was seen, reaching the highest improvement level at the three year follow-up (85.5 ± 7.2). The mean mHHS improvement recorded at the five year follow-up compared with preoperative scores was 39.1 ± 5.9.

CONCLUSIONS

AMIC is a valid procedure to repair medium-sized chondral defects on the acetabular side of the hip found during treatment of FAI and lead to long-term favourable outcomes.

LEVEL OF EVIDENCE

IV.

摘要

背景

髋臼软骨损伤常与髋关节撞击症(FAI)相关。治疗方案仍存在争议。

方法

2008年至2014年间,583例患者中有201例接受了关节镜下AMIC手术治疗III级和/或IV级髋臼软骨损伤。患者年龄在18至50岁之间;髋臼软骨损伤大小在2至4厘米之间;骨关节炎的放射学Tönnis分级≤2级。

结果

201例患者的平均随访时间为5年(8至2年)。与术前水平(80.3±8.3)相比,6个月时通过改良Harris髋关节评分(mHHS)测量有显著改善(p<0.001)。在每个先前的评估时间点都观察到持续改善,在三年随访时达到最高改善水平(85.5±7.2)。与术前评分相比,五年随访时记录的mHHS平均改善为39.1±5.9。

结论

AMIC是一种有效的手术方法,用于修复在FAI治疗过程中发现的髋关节髋臼侧中等大小的软骨损伤,并能带来长期良好的效果。

证据级别

IV级。

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