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关节镜技术治疗股骨髋臼撞击综合征中髋臼软骨损伤的五年疗效

Five-year results of arthroscopic techniques for the treatment of acetabular chondral lesions in femoroacetabular impingement.

作者信息

Mancini Donato, Fontana Andrea

机构信息

Department of Orthopaedic Surgery, Federico II University, Naples, Italy.

出版信息

Int Orthop. 2014 Oct;38(10):2057-64. doi: 10.1007/s00264-014-2403-1. Epub 2014 Jun 21.

Abstract

PURPOSE

This study assesses and compares the clinical outcomes of the arthroscopic matrix-induced autologous chondrocyte implant (MACI) and autologous matrix-induced chondrogenesis (AMIC) techniques for the treatment of acetabular chondral defects between 2 and 4 cm(2) consequent to femoral acetabular impingement.

METHODS

Fifty-seven consecutive patients were treated with the MACI (n = 26) or AMIC (n = 31) technique. Patients were assessed pre-operatively and up to five years using the modified Harris Hip Score (mHHS) to compare outcomes.

RESULTS

In both the MACI and AMIC groups, significant hip score improvements were measured over baseline levels at six months post-op (81.2 ± 8.4 for MACI, 80.3 ± 8.3 for AMIC, both p < 0.001). The mHHS continued to improve up to three years post-op and remained stable over time until the final five year follow-up. Statistically significant differences between the groups were not observed. The mean mHHS improvement at the five year follow-up with respect to preoperative level was 37.8 ± 5.9 and 39.1 ± 5.9 in patients who underwent MACI and AMIC, respectively (NS). Subgroup analysis of both MACI and AMIC treatment outcomes for patients with an initial chondral defect larger than 3 cm(2) yielded comparable results at each time point.

CONCLUSIONS

This study suggests that both arthroscopic MACI and AMIC are valid procedures to repair medium-sized chondral defects on the acetabular side of the hip found during treatment of femoroacetabular impingement. Due to its high sustainability and minimal invasiveness, the single-stage AMIC procedure can reduce total treatment time and minimise morbidity while providing the same beneficial effects as the two-stage MACI intervention.

摘要

目的

本研究评估并比较关节镜下基质诱导自体软骨细胞植入术(MACI)和自体基质诱导软骨生成术(AMIC)治疗因股骨髋臼撞击导致的2至4平方厘米髋臼软骨缺损的临床疗效。

方法

连续57例患者接受MACI(n = 26)或AMIC(n = 31)技术治疗。术前及术后长达五年采用改良Harris髋关节评分(mHHS)对患者进行评估以比较疗效。

结果

MACI组和AMIC组术后六个月时髋关节评分均较基线水平显著提高(MACI组为81.2±8.4,AMIC组为80.3±8.3,均p < 0.001)。mHHS在术后三年持续改善,此后随时间保持稳定直至最后五年随访。两组间未观察到统计学显著差异。MACI组和AMIC组患者在五年随访时相对于术前水平的mHHS平均改善值分别为37.8±5.9和39.1±5.9(无显著性差异)。对初始软骨缺损大于3平方厘米的患者进行MACI和AMIC治疗结果的亚组分析在每个时间点均得出了可比结果。

结论

本研究表明,关节镜下MACI和AMIC都是修复股骨髋臼撞击治疗中发现的髋关节髋臼侧中等大小软骨缺损的有效方法。由于其高可持续性和微创性,单阶段AMIC手术可减少总治疗时间并将发病率降至最低,同时提供与两阶段MACI干预相同的有益效果。

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