Vagin Olga, Beenhouwer David O
Department of Physiology, Geffen School of Medicine at UCLALos Angeles, CA, USA; VA Greater Los Angeles Healthcare SystemLos Angeles, CA, USA.
Department of Medicine, Geffen School of Medicine at UCLALos Angeles, CA, USA; Division of Infectious Diseases, VA Greater Los Angeles Health Care SystemLos Angeles, CA, USA.
Front Cell Dev Biol. 2016 Dec 20;4:143. doi: 10.3389/fcell.2016.00143. eCollection 2016.
Septins are small GTPases that play a role in several important cellular processes. In this review, we focus on the roles of septins in protein stabilization. Septins may regulate protein stability by: (1) interacting with proteins involved in degradation pathways, (2) regulating the interaction between transmembrane proteins and cytoskeletal proteins, (3) affecting the mobility of transmembrane proteins in lipid bilayers, and (4) modulating the interaction of proteins with their adaptor or signaling proteins. In this context, we discuss the role of septins in protecting four different proteins from degradation. First we consider botulinum neurotoxin serotype A (BoNT/A) and the contribution of septins to its extraordinarily long intracellular persistence. Next, we discuss the role of septins in stabilizing the receptor tyrosine kinases EGFR and ErbB2. Finally, we consider the contribution of septins in protecting hypoxia-inducible factor 1α (HIF-1α) from degradation.
Septins是一类小GTP酶，在多个重要的细胞过程中发挥作用。在本综述中，我们聚焦于Septins在蛋白质稳定性方面的作用。Septins可能通过以下方式调节蛋白质稳定性：（1）与参与降解途径的蛋白质相互作用；（2）调节跨膜蛋白与细胞骨架蛋白之间的相互作用；（3）影响跨膜蛋白在脂质双层中的流动性；（4）调节蛋白质与其衔接蛋白或信号蛋白的相互作用。在此背景下，我们讨论Septins在保护四种不同蛋白质免于降解方面的作用。首先，我们考虑A型肉毒杆菌神经毒素（BoNT/A）以及Septins对其异常长的细胞内持久性的贡献。接下来，我们讨论Septins在稳定受体酪氨酸激酶EGFR和ErbB2方面的作用。最后，我们考虑Septins在保护缺氧诱导因子1α（HIF-1α）免于降解方面的贡献。
