Benoit Béatrice, Poüs Christian, Baillet Anita
INSERM UMR-S 1193, UFR de Pharmacie, University Paris-Saclay, Orsay, France.
Laboratoire de Biochimie-Hormonologie, Hôpital Antoine Béclère, AP-HP, Hôpitaux Universitaires Paris-Saclay, Clamart, France.
Front Cell Dev Biol. 2023 Feb 17;11:1112319. doi: 10.3389/fcell.2023.1112319. eCollection 2023.
The cytoskeleton comprises three polymerizing structures that have been studied for a long time, actin microfilaments, microtubules and intermediate filaments, plus more recently investigated dynamic assemblies like septins or the endocytic-sorting complex required for transport (ESCRT) complex. These filament-forming proteins control several cell functions through crosstalks with each other and with membranes. In this review, we report recent works that address how septins bind to membranes, and influence their shaping, organization, properties and functions, either by binding to them directly or indirectly through other cytoskeleton elements.
细胞骨架由三种长期以来一直被研究的聚合结构组成，即肌动蛋白微丝、微管和中间丝，此外还有最近研究的动态组装体，如septin或运输所需的内吞分选复合体（ESCRT）。这些形成细丝的蛋白质通过彼此之间以及与膜的相互作用来控制多种细胞功能。在本综述中，我们报告了最近的研究工作，这些工作探讨了septin如何与膜结合，并通过直接结合或通过其他细胞骨架元件间接结合来影响膜的形状、组织、特性和功能。
