Institut des Neurosciences Paris-Saclay (Neuro-PSI), Cognition and Behaviour Department, UMR 9197, Université Paris Sud, CNRS, Université Paris Saclay, Orsay F-91405, France.
Center for Neural Science, New York University, New York, New York 10003, USA.
Nat Commun. 2017 Jan 9;8:13920. doi: 10.1038/ncomms13920.
Pavlovian aversive conditioning requires learning of the association between a conditioned stimulus (CS) and an unconditioned, aversive stimulus (US) but also involves encoding the time interval between the two stimuli. The neurobiological bases of this time interval learning are unknown. Here, we show that in rats, the dorsal striatum and basal amygdala belong to a common functional network underlying temporal expectancy and learning of a CS-US interval. Importantly, changes in coherence between striatum and amygdala local field potentials (LFPs) were found to couple these structures during interval estimation within the lower range of the theta rhythm (3-6 Hz). Strikingly, we also show that a change to the CS-US time interval results in long-term changes in cortico-striatal synaptic efficacy under the control of the amygdala. Collectively, this study reveals physiological correlates of plasticity mechanisms of interval timing that take place in the striatum and are regulated by the amygdala.
巴甫洛夫厌恶条件反射需要学习条件刺激 (CS) 和非条件、厌恶刺激 (US) 之间的关联，但也涉及到对两个刺激之间的时间间隔进行编码。这种时间间隔学习的神经生物学基础尚不清楚。在这里，我们发现在大鼠中，背侧纹状体和基底杏仁核属于一个共同的功能网络，该网络是时间预期和 CS-US 间隔学习的基础。重要的是，我们发现，在θ节律（3-6Hz）的较低范围内进行间隔估计时，纹状体和杏仁核局部场电位（LFPs）之间的相干性变化会在这些结构之间产生耦合。引人注目的是，我们还发现，CS-US 时间间隔的变化会导致在杏仁核控制下，皮质-纹状体突触效能的长期变化。总的来说，这项研究揭示了在纹状体中发生的、由杏仁核调节的间隔计时可塑性机制的生理相关性。
