• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

仙人掌茎提取物对不同脂多糖激活的小胶质细胞BV-2中过氧化物酶体功能的保护作用。

Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides.

作者信息

Saih Fatima-Ezzahra, Andreoletti Pierre, Mandard Stéphane, Latruffe Norbert, El Kebbaj M'Hammed Saïd, Lizard Gérard, Nasser Boubker, Cherkaoui-Malki Mustapha

机构信息

Laboratoire BioPeroxIL, Biochimie du Peroxysome, Inflammation et Métabolisme Lipidique, EA 7270, Unité de Formation et de Recherche des Sciences Vie, Terre et Environnement, 21000 Dijon, France.

Laboratoire BioPeroxIL, Université Bourgogne-Franche Comté, 6 Bd Gabriel, 21000 Dijon, France.

出版信息

Molecules. 2017 Jan 7;22(1):102. doi: 10.3390/molecules22010102.

DOI:10.3390/molecules22010102
PMID:28067864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6155690/
Abstract

In this study, we aimed to evaluate the antioxidant and anti-inflammatory properties of cactus cladode extracts in microglia BV-2 cells. Inflammation associated with microglia activation in neuronal injury can be achieved by LPS exposure. Using four different structurally and biologically well-characterized LPS serotypes, we revealed a structure-related differential effect of LPS on fatty acid β-oxidation and antioxidant enzymes in peroxisomes: -LPS decreased ACOX1 activity while -LPS reduced only catalase activity. Different cactus cladode extracts showed an antioxidant effect through microglial catalase activity activation and an anti-inflammatory effect by reducing nitric oxide (NO) LPS-dependent production. These results suggest that cactus extracts may possess a neuroprotective activity through the induction of peroxisomal antioxidant activity and the inhibition of NO production by activated microglial cells.

摘要

在本研究中，我们旨在评估仙人掌茎提取物对小胶质细胞BV-2的抗氧化和抗炎特性。神经元损伤中与小胶质细胞活化相关的炎症可通过暴露于脂多糖（LPS）来实现。使用四种结构和生物学特性明确的不同LPS血清型，我们揭示了LPS对过氧化物酶体中脂肪酸β-氧化和抗氧化酶的结构相关差异效应：A型LPS降低了酰基辅酶A氧化酶1（ACOX1）的活性，而B型LPS仅降低了过氧化氢酶的活性。不同的仙人掌茎提取物通过激活小胶质细胞的过氧化氢酶活性显示出抗氧化作用，并通过减少LPS依赖性一氧化氮（NO）的产生发挥抗炎作用。这些结果表明，仙人掌提取物可能通过诱导过氧化物酶体抗氧化活性和抑制活化小胶质细胞产生NO而具有神经保护活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/cc9a75a7ae29/molecules-22-00102-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/034397e487a2/molecules-22-00102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/e9950cc1a35e/molecules-22-00102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/934b9f3702dc/molecules-22-00102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/42c2265a39cc/molecules-22-00102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/b6a0b248ff42/molecules-22-00102-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/cc9a75a7ae29/molecules-22-00102-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/034397e487a2/molecules-22-00102-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/e9950cc1a35e/molecules-22-00102-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/934b9f3702dc/molecules-22-00102-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/42c2265a39cc/molecules-22-00102-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/b6a0b248ff42/molecules-22-00102-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a9dc/6155690/cc9a75a7ae29/molecules-22-00102-g006.jpg

相似文献

1
Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides.仙人掌茎提取物对不同脂多糖激活的小胶质细胞BV-2中过氧化物酶体功能的保护作用。
Molecules. 2017 Jan 7;22(1):102. doi: 10.3390/molecules22010102.
2
Lactic Acid Fermentation of Cactus Cladodes (Opuntia ficus-indica L.) Generates Flavonoid Derivatives with Antioxidant and Anti-Inflammatory Properties.仙人掌茎片（仙人掌）的乳酸发酵产生具有抗氧化和抗炎特性的类黄酮衍生物。
PLoS One. 2016 Mar 29;11(3):e0152575. doi: 10.1371/journal.pone.0152575. eCollection 2016.
3
The Antioxidant Effects of Thymoquinone in Activated BV-2 Murine Microglial Cells.对苯二酚在活化的BV-2小鼠小胶质细胞中的抗氧化作用
Neurochem Res. 2016 Dec;41(12):3227-3238. doi: 10.1007/s11064-016-2047-1. Epub 2016 Sep 1.
4
Protective Effect of Nopal Cactus () Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver.龙舌兰仙人掌籽油对短期脂多糖诱导的小鼠脑和肝炎症及过氧化物酶体功能紊乱的保护作用。
Int J Mol Sci. 2022 Oct 6;23(19):11849. doi: 10.3390/ijms231911849.
5
Inhibition of nitric oxide synthase expression in activated microglia and peroxynitrite scavenging activity by Opuntia ficus indica var. saboten.仙人掌对活化小胶质细胞中一氧化氮合酶表达的抑制作用及过氧亚硝酸盐清除活性
Phytother Res. 2006 Sep;20(9):742-7. doi: 10.1002/ptr.1942.
6
Hispolon Suppresses LPS- or LTA-Induced iNOS/NO Production and Apoptosis in BV-2 Microglial Cells.褐藻寡糖通过抑制 LPS 或 LTA 诱导的 BV-2 小胶质细胞中 iNOS/NO 的产生和凋亡。
Am J Chin Med. 2017;45(8):1649-1666. doi: 10.1142/S0192415X17500896. Epub 2017 Nov 9.
7
Apigetrin from Scutellaria baicalensis Georgi Inhibits Neuroinflammation in BV-2 Microglia and Exerts Neuroprotective Effect in HT22 Hippocampal Cells.黄芩中的芹菜素抑制BV-2小胶质细胞中的神经炎症并在HT22海马细胞中发挥神经保护作用。
J Med Food. 2016 Nov;19(11):1032-1040. doi: 10.1089/jmf.2016.0074.
8
Attenuation of inflammatory-mediated neurotoxicity by Saururus chinensis extract in LPS-induced BV-2 microglia cells via regulation of NF-κB signaling and anti-oxidant properties.通过调节NF-κB信号通路和抗氧化特性，三白草提取物减轻脂多糖诱导的BV-2小胶质细胞中炎症介导的神经毒性。
BMC Complement Altern Med. 2014 Dec 16;14:502. doi: 10.1186/1472-6882-14-502.
9
Supplementation of omega 3 fatty acids improves oxidative stress in activated BV2 microglial cell line.补充ω-3脂肪酸可改善活化的BV2小胶质细胞系中的氧化应激。
Int J Food Sci Nutr. 2015 May;66(3):293-9. doi: 10.3109/09637486.2014.986073. Epub 2015 Jan 13.
10
7-Ketocholesterol is increased in the plasma of X-ALD patients and induces peroxisomal modifications in microglial cells: Potential roles of 7-ketocholesterol in the pathophysiology of X-ALD.7-酮胆固醇在X-连锁肾上腺脑白质营养不良（X-ALD）患者的血浆中升高，并在小胶质细胞中诱导过氧化物酶体改变：7-酮胆固醇在X-ALD病理生理学中的潜在作用。
J Steroid Biochem Mol Biol. 2017 May;169:123-136. doi: 10.1016/j.jsbmb.2016.03.037. Epub 2016 Apr 1.

引用本文的文献

1
Fatty Acid Profile and Some Useful Biological Aspects of Borage, Calophyllum, and Prickly Pear Seed Oils: Implications for Health and Dietary Use.琉璃苣、红厚壳和仙人掌籽油的脂肪酸谱及一些有用的生物学特性：对健康和膳食应用的意义
Antioxidants (Basel). 2025 May 30;14(6):661. doi: 10.3390/antiox14060661.
2
Protective Effect of Nopal Cactus () Seed Oil against Short-Term Lipopolysaccharides-Induced Inflammation and Peroxisomal Functions Dysregulation in Mouse Brain and Liver.龙舌兰仙人掌籽油对短期脂多糖诱导的小鼠脑和肝炎症及过氧化物酶体功能紊乱的保护作用。
Int J Mol Sci. 2022 Oct 6;23(19):11849. doi: 10.3390/ijms231911849.
3

本文引用的文献

1
Argan oil prevents down-regulation induced by endotoxin on liver fatty acid oxidation and gluconeogenesis and on peroxisome proliferator-activated receptor gamma coactivator-1α, (PGC-1α), peroxisome proliferator-activated receptor α (PPARα) and estrogen related receptor α (ERRα).阿甘油可防止内毒素诱导的肝脏脂肪酸氧化、糖异生以及过氧化物酶体增殖物激活受体γ共激活因子-1α（PGC-1α）、过氧化物酶体增殖物激活受体α（PPARα）和雌激素相关受体α（ERRα）的下调。
Biochim Open. 2015 Oct 31;1:51-59. doi: 10.1016/j.biopen.2015.10.002. eCollection 2015.
2
Targeted Antioxidant, Catalase-SKL, Reduces Beta-Amyloid Toxicity in the Rat Brain.靶向抗氧化剂过氧化氢酶-SKL可降低大鼠脑中β-淀粉样蛋白的毒性。
Brain Pathol. 2017 Jan;27(1):86-94. doi: 10.1111/bpa.12368. Epub 2016 Jun 13.
3
spp. in Human Health: A Comprehensive Summary on Its Pharmacological, Therapeutic and Preventive Properties. Part 2.
人类健康中的物种：关于其药理、治疗和预防特性的全面总结。第2部分。
Plants (Basel). 2022 Sep 6;11(18):2333. doi: 10.3390/plants11182333.
4
Triticum vulgare extract exerts an anti-inflammatory action in two in vitro models of inflammation in microglial cells.普通小麦提取物在体外小胶质细胞炎症模型中发挥抗炎作用。
PLoS One. 2018 Jun 14;13(6):e0197493. doi: 10.1371/journal.pone.0197493. eCollection 2018.
5
Natural Products and Inflammation.天然产物与炎症
Molecules. 2017 Jan 12;22(1):120. doi: 10.3390/molecules22010120.
Schizandrin A Inhibits Microglia-Mediated Neuroninflammation through Inhibiting TRAF6-NF-κB and Jak2-Stat3 Signaling Pathways.五味子甲素通过抑制TRAF6-NF-κB和Jak2-Stat3信号通路抑制小胶质细胞介导的神经元炎症。
PLoS One. 2016 Feb 26;11(2):e0149991. doi: 10.1371/journal.pone.0149991. eCollection 2016.
4
Microglial cell dysregulation in brain aging and neurodegeneration.脑衰老和神经退行性变中的小胶质细胞失调。
Front Aging Neurosci. 2015 Jul 20;7:124. doi: 10.3389/fnagi.2015.00124. eCollection 2015.
5
Systemic inflammation and microglial activation: systematic review of animal experiments.全身炎症与小胶质细胞激活：动物实验的系统评价
J Neuroinflammation. 2015 Jun 6;12:114. doi: 10.1186/s12974-015-0332-6.
6
Thymoquinone inhibits lipopolysaccharide-induced inflammatory mediators in BV2 microglial cells.百里醌抑制脂多糖诱导的BV2小胶质细胞中的炎症介质。
Int Immunopharmacol. 2015 May;26(1):169-73. doi: 10.1016/j.intimp.2015.03.013. Epub 2015 Mar 21.
7
An expeditious synthesis of spinasterol and schottenol, two phytosterols present in argan oil and in cactus pear seed oil, and evaluation of their biological activities on cells of the central nervous system.快速合成刺蒺藜醇和菠菜甾醇（这两种植物甾醇存在于阿甘油和仙人掌籽油中）及其对中枢神经系统细胞生物活性的评估。
Steroids. 2015 Jul;99(Pt B):119-24. doi: 10.1016/j.steroids.2015.01.005. Epub 2015 Jan 13.
8
EOP, a newly synthesized ethyl pyruvate derivative, attenuates the production of inflammatory mediators via p38, ERK and NF-κB pathways in lipopolysaccharide-activated BV-2 microglial cells.EOP是一种新合成的丙酮酸乙酯衍生物，它通过p38、ERK和NF-κB途径，在脂多糖激活的BV-2小胶质细胞中减弱炎症介质的产生。
Molecules. 2014 Nov 25;19(12):19361-75. doi: 10.3390/molecules191219361.
9
Nopal cactus (Opuntia ficus-indica) as a source of bioactive compounds for nutrition, health and disease.霸王树仙人掌（仙人果仙人掌）作为营养、健康和疾病方面生物活性化合物的来源。
Molecules. 2014 Sep 17;19(9):14879-901. doi: 10.3390/molecules190914879.
10
Chemical composition and antibacterial activity of Opuntia ficus-indica f. inermis (cactus pear) flowers.无刺仙人掌（仙人掌果）花的化学成分及抗菌活性
J Med Food. 2014 Aug;17(8):908-14. doi: 10.1089/jmf.2013.0089. Epub 2014 Mar 20.