Nagurney Justine M, Fleischman William, Han Ling, Leo-Summers Linda, Allore Heather G, Gill Thomas M
Department of Emergency Medicine, Yale School of Medicine, New Haven, CT.
Robert Wood Johnson Foundation Clinical Scholars Program, Yale School of Medicine, New Haven, CT.
Ann Emerg Med. 2017 Apr;69(4):426-433. doi: 10.1016/j.annemergmed.2016.09.018. Epub 2017 Jan 6.
Among older persons, disability and functional decline are associated with increased mortality, institutionalization, and costs. The aim of the study was to determine whether illnesses and injuries leading to an emergency department (ED) visit but not hospitalization are associated with functional decline among community-living older persons.
From a cohort of 754 community-living older persons who have been followed with monthly interviews for up to 14 years, we matched 813 ED visits without hospitalization (ED only) to 813 observations without an ED visit or hospitalization (control). We compared the course of disability during the following 6 months between the 2 matched groups. To establish a frame of reference, we also compared the ED-only group with an unmatched group who were hospitalized after an ED visit (ED-hospitalized). Disability scores (range 0 [lowest] to 13 [highest]) were compared using generalized linear models adjusted for relevant covariates. Admission to a nursing home and mortality were evaluated as secondary outcomes.
The ED-only and control groups were well matched. For both groups, the mean age was 84 years, and 69% were women. The baseline disability scores were 3.4 and 3.6 in the ED-only and control groups, respectively. During the 6-month follow-up period, the ED-only group had significantly higher disability scores than the control group, with an adjusted risk ratio of 1.14 (95% confidence interval [CI] 1.09 to 1.19). Compared with participants in the ED-only group, those who were hospitalized after an ED visit had disability scores that were significantly higher (risk ratio 1.17; 95% CI 1.12 to 1.22). Both nursing home admissions (hazard ratio 3.11; 95% CI 2.05 to 4.72) and mortality (hazard ratio 1.93; 95% CI 1.07 to 3.49) were higher in the ED-only group versus control group during the 6-month follow-up period.
Although not as debilitating as an acute hospitalization, illnesses and injuries leading to an ED visit without hospitalization were associated with a clinically meaningful decline in functional status during the following 6 months, suggesting that the period after an ED visit represents a vulnerable time for community-living older persons.
在老年人中,残疾和功能衰退与死亡率增加、入住机构照料以及费用上升相关。本研究的目的是确定导致急诊就诊但未住院的疾病和损伤是否与社区居住老年人的功能衰退有关。
从一个对754名社区居住老年人进行了长达14年每月一次随访访谈的队列中,我们将813次未住院的急诊就诊(仅急诊)与813次未急诊就诊或住院的观察对象(对照组)进行匹配。我们比较了这两个匹配组在接下来6个月内的残疾进程。为了建立一个参照框架,我们还将仅急诊组与一组在急诊就诊后住院的未匹配组(急诊后住院组)进行了比较。使用针对相关协变量进行调整的广义线性模型比较残疾评分(范围从0[最低]到13[最高])。将入住养老院和死亡率作为次要结局进行评估。
仅急诊组和对照组匹配良好。两组的平均年龄均为84岁,69%为女性。仅急诊组和对照组的基线残疾评分分别为3.4和3.6。在6个月的随访期内,仅急诊组的残疾评分显著高于对照组,调整后的风险比为1.14(95%置信区间[CI]1.09至1.19)。与仅急诊组的参与者相比,急诊就诊后住院的参与者的残疾评分显著更高(风险比1.17;95%CI 1.12至1.22)。在6个月的随访期内,仅急诊组的养老院入住率(风险比3.11;95%CI 2.05至4.72)和死亡率(风险比1.93;95%CI 1.07至3.49)均高于对照组。
尽管导致急诊就诊但未住院的疾病和损伤不像急性住院那样使人衰弱,但在接下来的6个月内与功能状态出现具有临床意义的衰退有关,这表明急诊就诊后的时期是社区居住老年人的脆弱时期。