Vannucci Campos Diego, Lopim Glauber Menezes, da Silva Daiana Aparecida, de Almeida Alexandre Aparecido, Amado Debora, Arida Ricardo Mario
Departamento de Fisiologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Departamento de Farmacologia, Universidade Federal de São Paulo (UNIFESP), São Paulo, SP, Brazil.
Physiol Behav. 2017 Mar 15;171:120-126. doi: 10.1016/j.physbeh.2016.12.040. Epub 2017 Jan 6.
Epilepsy is the most common neurological chronic condition worldwide, affecting about 2% of world population. Temporal lobe epilepsy (TLE) reaches 40% of all cases of this condition, and it is highly refractory to pharmacological treatment. Physical activity has been suggested as complementary therapy for epilepsy. However, there is no consistent information whether all these effects are plenty applicable to females, since clinical and experimental studies concerning physical exercise and epilepsy are largely performed in males. Females are worthy of special attention due to gender specific particularities such as hormonal cyclical rhythm and possible pregnancy. Therefore, this study aimed to investigate the impact of two types of exercise programs (Forced and Voluntary) in female Wistar rats submitted to temporal lobe epilepsy induced by pilocarpine.
Animals were divided into four groups: Control (healthy), Epilepsy, Epilepsy/Forced (exercise in a treadmill) and Epilepsy/Voluntary (free access to wheel). Behavioral and histological analyses were evaluated among groups.
Voluntary exercise was able to reduce seizure frequency and anovulatory estrous cycle occurrence. Yet, both types of exercise attenuated the mossy fiber sprouting in dentate gyrus.
Our results indicate that voluntary exercise exerts a positive effect on epilepsy in female gender. Further investigations are necessary to better elucidate mechanisms involved in these responses, since these effects do not act in the same manner in male and female rats.
癫痫是全球最常见的神经慢性疾病，影响着约2%的世界人口。颞叶癫痫（TLE）占该疾病所有病例的40%，并且对药物治疗具有高度难治性。体育活动已被建议作为癫痫的辅助治疗方法。然而，由于关于体育锻炼与癫痫的临床和实验研究大多在男性中进行，尚无一致信息表明所有这些影响是否完全适用于女性。由于女性具有激素周期性节律和可能怀孕等性别特异性特点，她们值得特别关注。因此，本研究旨在调查两种运动方案（强迫运动和自主运动）对接受匹罗卡品诱导的颞叶癫痫的雌性Wistar大鼠的影响。
将动物分为四组：对照组（健康）、癫痫组、癫痫/强迫运动组（在跑步机上运动）和癫痫/自主运动组（可自由使用转轮）。对各组进行行为学和组织学分析评估。
自主运动能够降低癫痫发作频率和无排卵发情周期的发生率。然而，两种运动类型均减轻了齿状回中苔藓纤维发芽。
我们的结果表明，自主运动对雌性癫痫具有积极作用。由于这些作用在雄性和雌性大鼠中的表现方式不同，因此需要进一步研究以更好地阐明这些反应所涉及的机制。
