Navarro N M, Krawczyk M C, Boccia M M, Blake M G
Universidad de Buenos Aires, CONICET, Facultad de Medicina, Departamento de Fisiología, Instituto de Fisiología y Biofísica Bernardo Houssay (IFIBIO), Paraguay, 2155, 7th floor, C1121ABG, Buenos Aires, Argentina.
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Cátedra de Farmacología, Junín, 956, 5th floor, C1113AAC, Buenos Aires, Argentina.
Physiol Behav. 2017 Mar 15;171:192-198. doi: 10.1016/j.physbeh.2016.12.042. Epub 2017 Jan 6.
Pre-training administration of scopolamine (SCP) resembles situations of cholinergic dysfunction, leading to memory impairment of mice trained in an inhibitory avoidance task. We suggest here that SCP does not impair memory formation, but acquisition is affected in a way that reduces the strength of the stored memory, thus making this memory less able to control behavior when tested. Hence, a memory trace is stored, but is poorly expressed during the test. Although weakly expressed, this memory shows extinction during successive tests, and can be strengthened by using a reminder. Our results indicate that memories stored under cholinergic dysfunction conditions seem absent or lost, but are in fact present and experience common memory processes, such as extinction, and could be even recovered by using appropriate protocols.
东莨菪碱（SCP）的预训练给药类似于胆碱能功能障碍的情况，会导致在抑制性回避任务中训练的小鼠出现记忆障碍。我们在此提出，SCP不会损害记忆形成，但会以降低存储记忆强度的方式影响记忆获取，从而使这种记忆在测试时控制行为的能力降低。因此，记忆痕迹被存储，但在测试期间表达不佳。虽然表达较弱，但这种记忆在连续测试中会出现消退，并且可以通过使用提示来加强。我们的结果表明，在胆碱能功能障碍条件下存储的记忆看似不存在或丢失，但实际上是存在的，并且经历了诸如消退等常见的记忆过程，甚至可以通过使用适当的方案恢复。
