Amiya Eisuke
Eisuke Amiya, Department of Cardiovascular Medicine, Graduate School of Medicine, the University of Tokyo, Bunkyo-ku, Tokyo 113-8655, Japan.
World J Cardiol. 2016 Dec 26;8(12):689-694. doi: 10.4330/wjc.v8.i12.689.
Reactive oxygen species (ROS) and oxidative stress are closely associated with the development of atherosclerosis, and the most important regulator of ROS production in endothelial cells is NADPH oxidase. Activation of NADPH oxidase requires the assembly of multiple subunits into lipid rafts, which include specific lipid components, including free cholesterol and specific proteins. Disorders of lipid metabolism such as hyperlipidemia affect the cellular lipid components included in rafts, resulting in modification of cellular reactions that produce ROS. In the similar manner, several pathways associating ROS production are affected by the presence of lipid disorder through raft compartments. In this manuscript, we review the pathophysiological implications of hyperlipidemia and lipid rafts in the production of ROS.
活性氧（ROS）和氧化应激与动脉粥样硬化的发展密切相关，内皮细胞中ROS产生的最重要调节因子是NADPH氧化酶。NADPH氧化酶的激活需要多个亚基组装到脂筏中，脂筏包括特定的脂质成分，如游离胆固醇和特定蛋白质。脂质代谢紊乱如高脂血症会影响脂筏中包含的细胞脂质成分，从而导致产生ROS的细胞反应发生改变。同样，通过脂筏区室，几种与ROS产生相关的途径也会受到脂质紊乱的影响。在本手稿中，我们综述了高脂血症和脂筏在ROS产生中的病理生理学意义。
