Chen Kang, Zhou Fangfei, Zhang Jian, Li Pin, Zhang Yumei, Yang Baoru
Food Sciences, Department of Life Technologies, University of Turku, 20014 Turku, Finland.
Department of Nutrition and Food Hygiene, School of Public Health, Beijing University, Beijing 100191, China.
Foods. 2022 Aug 17;11(16):2481. doi: 10.3390/foods11162481.
Sea buckthorn berries have been reported to have beneficial effects on plasma lipid profile and cardiovascular health. This study aimed to investigate the impact of intervention with sea buckthorn berry puree on plasma metabolomics profile and gut microbiota in hypercholesterolemic subjects. A total of 56 subjects with hypercholesterolemia consumed 90 g of sea buckthorn berry puree daily for 90 days, and plasma metabolomic profile was studied at 0 (baseline), 45, and 90 days of intervention by using proton nuclear magnetic resonance spectroscopy (H NMR). Gut microbiota composition was analyzed at the baseline and after 90 days of supplementation by using high-throughput sequencing. The plasma metabolic profile was significantly altered after 45 days of intervention as compared to the baseline (day 0). A clear trend of returning to the baseline metabolomic profile was observed in plasma when the intervention extended from 45 days to 90 days. Despite this, the levels of several key plasma metabolites such as glucose, lactate, and creatine were lowered at day 90 compared to the baseline levels, suggesting an improved energy metabolism in those patients. In addition, intervention with sea buckthorn puree enriched butyrate-producing bacteria and other gut microbes linked to lipid metabolisms such as and while depleting associated with increased risks of cardiovascular disease. These findings indicate that sea buckthorn berries have potential in modulating energy metabolism and the gut microbiota composition in hypercholesterolemic patients.
据报道，沙棘浆果对血脂水平和心血管健康有益。本研究旨在调查高胆固醇血症患者食用沙棘果泥干预对血浆代谢组学特征和肠道微生物群的影响。共有56名高胆固醇血症患者连续90天每天食用90克沙棘果泥，并在干预的第0天（基线）、第45天和第90天使用质子核磁共振波谱（H NMR）研究血浆代谢组学特征。在基线期和补充90天后，使用高通量测序分析肠道微生物群组成。与基线期（第0天）相比，干预45天后血浆代谢特征发生了显著变化。当干预从45天延长至90天时，血浆中观察到明显的恢复至基线代谢组学特征的趋势。尽管如此，与基线水平相比，在第90天时几种关键血浆代谢物如葡萄糖、乳酸和肌酸的水平降低，表明这些患者的能量代谢得到改善。此外，沙棘果泥干预增加了产生丁酸盐的细菌和其他与脂质代谢相关的肠道微生物，如 和 ，同时减少了与心血管疾病风险增加相关的 。这些发现表明，沙棘浆果在调节高胆固醇血症患者的能量代谢和肠道微生物群组成方面具有潜力。
