环（组氨酸-脯氨酸）加锌治疗对糖尿病与阿尔茨海默病之间代谢关系的影响。
Metabolic relationship between diabetes and Alzheimer's Disease affected by Cyclo(His-Pro) plus zinc treatment.
作者信息
Song Moon K, Bischoff David S, Song Albert M, Uyemura Koichi, Yamaguchi Dean T
机构信息
VA Greater Los Angeles Healthcare System, 16111, Plummer Street, North Hills, CA 91343; UCLA School of Medicine, 1O833 Le Conte Avenue, Los Angeles, CA 90095.
Kaiser Permanente Medical Center, 13651 Willard Street, Panorama City, CA 91402.
出版信息
BBA Clin. 2016 Oct 2;7:41-54. doi: 10.1016/j.bbacli.2016.09.003. eCollection 2017 Jun.
BACKGROUND
Association of Alzheimer's Disease (AD) with Type 2 Diabetes (T2D) has been well established. Cyclo(His-Pro) plus zinc (Cyclo-Z) treatment ameliorated diabetes in rats and similar improvements have been seen in human patients. Treatment of amyloid precursor protein (APP) transgenic mice with Cyclo-Z exhibited memory improvements and significantly reduced Aβ-40 and Aβ-42 protein levels in the brain tissues of the mice.
SCOPE OF REVIEW
Metabolic relationship between AD and T2D will be described with particular attention to insulin sensitivity and Aβ degradation in brain and plasma tissues. Mechanistic effect of insulin degrading enzyme (IDE) in decreasing blood glucose and brain Aβ levels will be elucidated. Cyclo-Z effects on these biochemical parameters will be discussed.
MAJOR CONCLUSION
Stimulation of IDE synthesis is effective for the clinical treatment of metabolic diseases including AD and T2D.
GENERAL SIGNIFICANCE
Cyclo-Z might be the effective treatment of AD and T2D by stimulating IDE synthesis.
背景
阿尔茨海默病（AD）与2型糖尿病（T2D）之间的关联已得到充分证实。环（组氨酸-脯氨酸）加锌（Cyclo-Z）治疗可改善大鼠的糖尿病，在人类患者中也观察到了类似的改善。用Cyclo-Z治疗淀粉样前体蛋白（APP）转基因小鼠，小鼠脑组织中的记忆力得到改善，且Aβ-40和Aβ-42蛋白水平显著降低。
综述范围
将描述AD与T2D之间的代谢关系，特别关注脑和血浆组织中的胰岛素敏感性及Aβ降解。将阐明胰岛素降解酶（IDE）在降低血糖和脑Aβ水平方面的作用机制。将讨论Cyclo-Z对这些生化参数的影响。
主要结论
刺激IDE合成对包括AD和T2D在内的代谢性疾病临床治疗有效。
普遍意义
Cyclo-Z可能通过刺激IDE合成有效治疗AD和T2D。
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