过敏性哮喘患者血清中的微量元素状况
Trace Elements Status in Sera of Patients with Allergic Asthma.
作者信息
Ariaee Nazila, Farid Reza, Shabestari Fahimeh, Shabestari Mohamad, Jabbari Azad Farahzad
机构信息
Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
出版信息
Rep Biochem Mol Biol. 2016 Oct;5(1):20-25.
BACKGROUND
Asthma is a multifactorial disease and its severity varies with the inflammatory grade. There are conflicting reports about the roles of trace elements in asthma. This study examined the effects of zinc (Zn), copper (Cu), and selenium (Se) concentrations in sera of patients with allergic asthma attending Ghaem Hospital, Mashhad, Iran.
METHODS
Forty-nine patients, aged 10 to 50 years, with asthma in moderate or severe stages, and 24 healthy controls, were enrolled in this study. After demographic data collection and clinical evaluations, the subjects' serum concentrations of Zn, Cu, and Se were measured via atomic absorbency.
RESULTS
Mean serum levels of Zn and Se in patients with allergic asthma were lower than in the healthy control group, but the Cu concentration in sera of patients with allergic asthma was slightly higher than healthy controls.
CONCLUSION
Low levels of trace elements, specifically Zn, may have a role in the pathogenesis of allergic asthma; replacement of these elements may be an effective treatment.
背景
哮喘是一种多因素疾病，其严重程度随炎症分级而变化。关于微量元素在哮喘中的作用存在相互矛盾的报道。本研究检测了伊朗马什哈德加姆医院过敏性哮喘患者血清中锌（Zn）、铜（Cu）和硒（Se）浓度的影响。
方法
本研究纳入了49例年龄在10至50岁之间、处于中度或重度阶段的哮喘患者以及24名健康对照者。在收集人口统计学数据和进行临床评估后，通过原子吸收法测量受试者血清中Zn、Cu和Se的浓度。
结果
过敏性哮喘患者的血清Zn和Se平均水平低于健康对照组，但过敏性哮喘患者血清中的Cu浓度略高于健康对照组。
结论
微量元素水平低，特别是Zn，可能在过敏性哮喘的发病机制中起作用；补充这些元素可能是一种有效的治疗方法。
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