Cancer Epidemiology Branch, National Cancer Center, Goyang-si, Republic of Korea.
PLoS One. 2011;6(8):e23196. doi: 10.1371/journal.pone.0023196. Epub 2011 Aug 10.
We investigated the association of colorectal cancer risk factors with different colorectal cancer subsites to assess etiological differences for cancers of the proximal colon, distal colon, and rectum. Included in this study were 869,725 men and 395,501 women who participated in a health examination provided by the Korean National Health System between 1996 and 1997. During up to 7 years of follow-up, 4,144 incident colorectal cancer cases were detected (3,051 men and 1,093 women). Greater height was associated with elevated risk for distal colon cancer and rectal cancer in both men and women. Family history of cancer was associated with higher risk for cancers of the proximal colon in men and distal colon in both men and women. Frequent alcohol consumption and consuming high amounts of alcohol were associated with elevated risk for distal colon cancer in men and higher risk for rectal cancer in women. Frequent meat consumption was associated with risk for proximal colon cancer in men and for rectal cancer in women. Our findings suggest that risk factors for colorectal cancer are different by subsites of colon and rectum, as well as by sex.
我们研究了结直肠癌风险因素与不同结直肠癌部位之间的关联，以评估近端结肠、远端结肠和直肠癌症的病因差异。本研究纳入了 869725 名男性和 395501 名女性，他们于 1996 年至 1997 年期间参加了韩国国家健康系统提供的健康检查。在长达 7 年的随访期间，共发现 4144 例新发结直肠癌病例（男性 3051 例，女性 1093 例）。身高较高与男性和女性的远端结肠癌和直肠癌风险升高相关。男性有癌症家族史与近端结肠癌风险升高有关，男性和女性的远端结肠癌风险也升高。男性频繁饮酒和摄入大量酒精与远端结肠癌风险升高有关，女性直肠癌风险升高有关。男性频繁食用肉类与近端结肠癌风险有关，女性与直肠癌风险有关。我们的研究结果表明，结直肠癌的风险因素因结肠和直肠的部位以及性别而异。
