Park Sang Woo, Cho Eunae, Jun Chung Hwan, Choi Sung Kyu, Kim Hyun Soo, Park Chang Hwan, Rew Jong Sun, Cho Sung Bum, Kim Hee Joon, Han Mingui, Cho Kyu Man
Division of Gastroenterology, Department of Internal Medicine Department of Surgery, Chonnam National University Hospital, Gwangju, South Korea.
Medicine (Baltimore). 2017 Jan;96(1):e5860. doi: 10.1097/MD.0000000000005860.
Ectopic variceal bleeding is a rare (2-5%) but fatal gastrointestinal bleed in patients with portal hypertension. Patients with ectopic variceal bleeding manifest melena, hematochezia, or hematemesis, which require urgent managements. Definitive therapeutic modalities of ectopic varices are not yet standardized because of low incidence. Various therapeutic modalities have been applied on the basis of the experiences of experts or availability of facilities, with varying results.
We have encountered eight cases of gastrointestinal ectopic variceal bleeding in five patients in the last five years.
All patients were diagnosed with liver cirrhosis presenting melena or hematemesis.
All patients were treated with various endoscopic modalities (endoscopic variceal obturation [EVO] with cyanoacrylate in five cases, endoscopic variceal band ligation (EVL) in two cases, hemoclipping in one case).
Satisfactory hemostasis was achieved without radiologic interventions in all cases. EVO and EVL each caused one case of portal biliopathy, and EVL induced ulcer bleeding in one case.
EVO generally accomplished better results of variceal obturations than EVL or hemoclipping, without serious adverse events. EVO may be an effective modality for control of ectopic variceal bleeding without radiologic intervention or surgery.
异位静脉曲张出血在门静脉高压患者中是一种罕见(2%-5%)但致命的胃肠道出血。异位静脉曲张出血的患者表现为黑便、便血或呕血,需要紧急处理。由于发病率低,异位静脉曲张的确定性治疗方式尚未标准化。基于专家经验或设备可用性,已应用了各种治疗方式,结果各异。
在过去五年中,我们遇到了5例患者中的8例胃肠道异位静脉曲张出血病例。
所有患者均被诊断为肝硬化并出现黑便或呕血。
所有患者均接受了各种内镜治疗方式(5例使用氰基丙烯酸酯进行内镜下静脉曲张闭塞术[EVO],2例进行内镜下静脉曲张套扎术[EVL],1例进行止血夹夹闭术)。
所有病例均在未进行放射学干预的情况下实现了满意的止血。EVO和EVL各导致1例门静脉胆管病,EVL导致1例溃疡出血。
一般来说,EVO在静脉曲张闭塞方面比EVL或止血夹夹闭术取得了更好的效果,且无严重不良事件。EVO可能是一种无需放射学干预或手术即可控制异位静脉曲张出血的有效方式。