Kasperk Christian, Georgescu Carmen, Nawroth Peter
Medizinische Universitätsklinik Heidelberg, Abteilung Innere Medizin I und Klinische Chemie, INF, Heidelberg.
Department of Endocrinology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Rumänien.
Exp Clin Endocrinol Diabetes. 2017 Apr;125(4):213-217. doi: 10.1055/s-0042-123036. Epub 2017 Jan 10.
Diabetes mellitus and bone metabolism affect mesenchymal tissues and have numerous epidemiological and pathophysiological associations in common. Diabetes mellitus affects bone metabolism and increases fracture risk. The pathophysiological mechanims how type 1 and type 2 diabetes impair bone metabolism and bone strength may differ which is outlined in this review. Direct metabolic effects in additon to centrally controlled endocrine loops exert suppressive effects on bone formation and may also stimulate bone Resorption. Decreased bone formation in combination with increased bone resorption strongly increases fracture risk.
糖尿病和骨代谢会影响间充质组织，并且在流行病学和病理生理学方面有许多共同的关联。糖尿病会影响骨代谢并增加骨折风险。1型和2型糖尿病损害骨代谢和骨强度的病理生理机制可能有所不同，本文对此进行了概述。除了中枢控制的内分泌环路外，直接的代谢作用对骨形成产生抑制作用，还可能刺激骨吸收。骨形成减少与骨吸收增加相结合会大大增加骨折风险。
