Fromme Hermann, Wöckner Mandy, Roscher Eike, Völkel Wolfgang
Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, Pfarrstrasse 3, D-80538 Munich, Germany; Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Ludwig-Maximilians-University, Ziemssenstrasse 1, D-80336 Munich, Germany.
Bavarian Health and Food Safety Authority, Department of Chemical Safety and Toxicology, Pfarrstrasse 3, D-80538 Munich, Germany.
Int J Hyg Environ Health. 2017 Apr;220(2 Pt B):455-460. doi: 10.1016/j.ijheh.2016.12.014. Epub 2017 Jan 4.
Perfluorinated compounds are fully fluorinated anthropogenic substances that have been used in various products, applications, and industrial processes. Due to their persistence and toxic effects, some of them are restricted, and therefore replacement products have been developed. The aim of the study was to quantify the body burden of different perfluorinated substances in two adult populations living close to or about 80km apart from a former perfluorooctanoate (PFOA) production plant who are exposed via drinking water, and in a control population. In this plant, the replacement emulsifier 3H-perfluoro-3-[(3-methoxy-propoxy)propanoic acid] (ADONA) has been used in the production of fluoropolymers since 2008. We quantified 7 perfluorinated compounds and ADONA in a total of 396 plasma samples collected at different time points. With regard to samples collected in 2015 or 2016, the highest 95th percentile levels were 13.5μg/l for perfluorooctane sulfonate (PFOS), 3.0μg/l for perfluorononanoate (PFNA), and 1.5μg/l for perfluorohexane sulfonate (PFHxS). For PFOA, the highest 95th percentile was found at the site close to the facility (85.5μg/l), while in the control region the value was 2.4μg/l. Overall, the concentration of PFOA and PFOS declined over time in all study regions. ADONA was detected only in few samples slightly above the limit of quantification (0.2μg/l). While health risks related to ADONA are unlikely under the present exposure situation, the exposure to PFOA via tap water should be reduced markedly, especially for the population living close to the plant.
全氟化合物是完全氟化的人为物质，已被用于各种产品、应用和工业过程中。由于它们的持久性和毒性作用，其中一些已受到限制，因此已开发出替代产品。本研究的目的是量化居住在距一家前全氟辛酸（PFOA）生产厂约80公里或更近的两个成年人群体中不同全氟物质的体内负荷，这两个人群通过饮用水接触这些物质，同时也对一个对照人群进行了量化。自2008年以来，该工厂在含氟聚合物生产中使用了替代乳化剂3H-全氟-3-[(3-甲氧基-丙氧基)丙酸]（ADONA）。我们在不同时间点收集的总共396份血浆样本中对7种全氟化合物和ADONA进行了量化。对于2015年或2016年采集的样本，全氟辛烷磺酸（PFOS）的第95百分位数最高水平为13.5μg/l，全氟壬酸（PFNA）为3.0μg/l，全氟己烷磺酸（PFHxS）为1.5μg/l。对于PFOA，在靠近工厂的地点发现第95百分位数最高（85.5μg/l），而在对照区域该值为2.4μg/l。总体而言，所有研究区域中PFOA和PFOS的浓度随时间下降。仅在少数略高于定量限（0.2μg/l）的样本中检测到ADONA。虽然在当前暴露情况下与ADONA相关的健康风险不太可能存在，但通过自来水接触PFOA的情况应显著降低，尤其是对于居住在工厂附近的人群。
