Gueye M, Kane Gueye S M, Ndiaye Gueye M D, Niasse Dia F, Gassama O, Diallo M, Moreau J C
Clinique Gynécologique et Obstricale, EPS Aristide Le Dantec. 3001 Dakar, Sénégal.
Med Sante Trop. 2016 Nov 1;26(4):377-381. doi: 10.1684/mst.2016.0637.
The aim of this study was to determine the clinical features and outcomes of women younger than 35 years with breast cancer. This study was performed at Gynecologic and Obstetric Clinic of Dakar Teaching Hospital and retrospectively reviewed the records of all women younger than 35 years seen in our department for histologically proven breast cancer. Data were analyzed with SPSS software (Statistical Package for Social Science) Version 23. Between 2007 and 2015, 62 women with breast cancer met the inclusion criteria and were included. The incidence of women in this age group treated in our department was 22.6%. The median age at diagnosis was 29.7 years. The mean time to consultation was 12.5 months, and the disease was locally advanced at diagnosis in 79% of cases. Histological study found 85.5% of cancers were invasive ductal carcinoma. The immunohistochemical study found positive hormone receptors in 12 women (19.4%) and overexpression of HER-2 in 8 (12.9%). Chemotherapy was performed in 54 patients (87.1%), and surgery in 47 (62.9%). Recurrence occurred in 12. In all, 22 women died (35.5%) by the end of the study period. Mean survival was 36.7 months (CI 29.5 to 43.9) and median survival 39.7 months (CI 22.1 to 57.5). This high incidence rate in our study is consistent with that found in young African-American women and is worrisome. These results seem to point towards a genetic origin and call for a thorough search of the profile. They also call also for the involvement of pathologists and collaboration with other research teams.
本研究的目的是确定35岁以下乳腺癌女性的临床特征和预后。本研究在达喀尔教学医院妇产科诊所进行，回顾性分析了在我们科室就诊的所有35岁以下经组织学证实为乳腺癌的女性的病历。数据采用SPSS软件（社会科学统计软件包）23版进行分析。2007年至2015年期间，62例乳腺癌女性符合纳入标准并被纳入研究。在我们科室接受治疗的该年龄组女性的发病率为22.6%。诊断时的中位年龄为29.7岁。平均就诊时间为12.5个月，79%的病例在诊断时疾病已局部进展。组织学研究发现85.5%的癌症为浸润性导管癌。免疫组化研究发现12名女性（19.4%）激素受体呈阳性，8名女性（12.9%）HER-2过表达。54例患者（87.1%）接受了化疗，47例患者（62.9%）接受了手术。12例出现复发。到研究期结束时，共有22名女性死亡（35.5%）。平均生存期为36.7个月（95%置信区间29.5至43.9），中位生存期为39.7个月（95%置信区间22.1至57.5）。我们研究中的这一高发病率与年轻非裔美国女性中的发病率一致且令人担忧。这些结果似乎指向遗传起源，需要对其特征进行全面研究。它们还呼吁病理学家的参与以及与其他研究团队的合作。
