Dano Domitille, Hénon Clémence, Sarr Ousseynou, Ka Kanta, Ba Mouhamadou, Badiane Awa, Thiam Ibrahima, Diene Papa, Diop Mamadou, Dem Ahmadou, Marino Patricia, Mancini Julien, Annede Pierre, Gonçalves Anthony, Diouf Doudou, Monneur Audrey
Institut Paoli-Calmettes, Marseille, France.
Institut Gustave Roussy, Villejuif, France.
J Glob Oncol. 2019 Jul;5:1-9. doi: 10.1200/JGO.19.00106.
The prevalence of breast cancer is increasing in low- to middle-income countries such as Senegal. Our prospective study assessed the quality of life (QoL) of patients with breast cancer undergoing chemotherapy in Senegal.
Our study included women with breast cancer undergoing chemotherapy as initial treatment at the Center Aristide Le Dantec University Hospital in Dakar. Clinical, sociodemographic, and QoL data were collected and analyzed at three different times: baseline, 3 months, and 6 months after the start of systemic therapy. Health-related QoL was assessed using a Functional Assessment of Cancer Therapies-Breast (FACT-B) questionnaire after translation into the Wolof language. Linear mixed-effects models were performed to assess the changes in QoL scores.
Between July 2017 and February 2018, 120 patients were included in the study. Their median age was 45 years. Most patients (n = 105; 92%) had locally advanced disease (T3 to T4 stage) and lymph node involvement (n = 103; 88%), and half had metastatic disease. The FACT-B total scores significantly improved over time (β = 1.58; 95% CI, 0.50 to 2.67; < .01). Nausea and vomiting were significantly associated with a decrease in FACT-B total scores (β = -16.89, 95% CI, -29.58 to -4.24, = .012; and β = -13.44, 95% CI, -25.15 to -1.72, = .028, respectively).
Our study confirmed the feasibility of standardized QoL assessment in Senegalese patients with breast cancer. Our results indicated a potential improvement of QoL over the course of chemotherapy. Optimizing nausea and vomiting prevention may improve QoL.
在塞内加尔等低收入和中等收入国家，乳腺癌的患病率正在上升。我们的前瞻性研究评估了塞内加尔接受化疗的乳腺癌患者的生活质量（QoL）。
我们的研究纳入了在达喀尔阿里斯蒂德·勒丹泰克大学中心医院接受化疗作为初始治疗的乳腺癌女性患者。在全身治疗开始后的三个不同时间点收集并分析临床、社会人口统计学和生活质量数据：基线、3个月和6个月。在翻译成沃洛夫语后，使用癌症治疗功能评估-乳腺癌（FACT-B）问卷评估与健康相关的生活质量。进行线性混合效应模型以评估生活质量得分的变化。
2017年7月至2018年2月期间，120名患者纳入研究。她们的中位年龄为45岁。大多数患者（n = 105；92%）患有局部晚期疾病（T3至T4期）且有淋巴结受累（n = 103；88%），一半患者有转移性疾病。FACT-B总分随时间显著改善（β = 1.58；95% CI，0.50至2.67；P <.01）。恶心和呕吐与FACT-B总分降低显著相关（β分别为-16.89，95% CI，-29.58至-4.24，P =.012；以及β = -13.44，95% CI，-25.15至-1.72，P =.028）。
我们的研究证实了在塞内加尔乳腺癌患者中进行标准化生活质量评估的可行性。我们的结果表明化疗过程中生活质量有潜在改善。优化恶心和呕吐的预防可能会改善生活质量。
