首例接受实验性疗法的新生儿从埃博拉病毒病中康复。
First Newborn Baby to Receive Experimental Therapies Survives Ebola Virus Disease.
作者信息
Dörnemann Jenny, Burzio Chiara, Ronsse Axelle, Sprecher Armand, De Clerck Hilde, Van Herp Michel, Kolié Marie-Claire, Yosifiva Vesselina, Caluwaerts Severine, McElroy Anita K, Antierens Annick
机构信息
Médecins Sans Frontières, Brussels.
Médecins Sans Frontières, Conakry, Guinea.
出版信息
J Infect Dis. 2017 Jan 15;215(2):171-174. doi: 10.1093/infdis/jiw493.
A neonate born to an Ebola virus-positive woman was diagnosed with Ebola virus infection on her first day of life. The patient was treated with monoclonal antibodies (ZMapp), a buffy coat transfusion from an Ebola survivor, and the broad-spectrum antiviral GS-5734. On day 20, a venous blood specimen tested negative for Ebola virus by quantitative reverse-transcription polymerase chain reaction. The patient was discharged in good health on day 33 of life. Further follow-up consultations showed age-appropriate weight gain and neurodevelopment at the age of 12 months. This patient is the first neonate documented to have survived congenital infection with Ebola virus.
一名埃博拉病毒检测呈阳性的女性所生的新生儿在出生第一天就被诊断出感染了埃博拉病毒。该患者接受了单克隆抗体（ZMapp）、一名埃博拉幸存者的白膜输血以及广谱抗病毒药物GS-5734的治疗。在第20天，一份静脉血标本通过定量逆转录聚合酶链反应检测埃博拉病毒呈阴性。该患者在出生第33天健康出院。进一步的随访咨询显示，该患者在12个月大时体重增长和神经发育符合年龄标准。该患者是有记录以来首例从先天性埃博拉病毒感染中存活下来的新生儿。
Zotero 插件