Takahashi Shizuka, Adachi Kobu, Suzuki Yukihiko, Maeno Atsuko, Nakazawa Mitsuru
Department of Ophthalmology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Biomed Res Int. 2016;2016:4256183. doi: 10.1155/2016/4256183. Epub 2016 Dec 15.
. To characterize the profiles for inflammatory cytokines in the vitreous fluid from patients with rhegmatogenous retinal detachment (RRD) by comparing those of other vitreoretinal diseases and to analyze the correlation between intravitreal cytokines and clinical features. . Vitreous fluid was obtained at the time of surgery from 28 RRD eyes. Vitreous fluid was similarly collected from patients with macular hole (MH), epiretinal membrane, proliferative diabetic retinopathy (PDR), and retinal vein occlusion as controls. Twenty-seven cytokines were measured. Intravitreal cytokine profiles in RRD were characterized by comparing these with those in other vitreoretinal diseases. We also analyzed the correlations between vitreous cytokines and clinical features. . There were statistical differences in the MCP-1, MIP-1, and IP-10 between the RRD and MH, while the IL-6 and IL-8 exhibited levels that were between those for the PDR and MH. MIP-1 was significantly correlated to both the extent and duration of the RRD, while IL-8 was significantly correlated to the extent of the RRD. . MCP-1, MIP-1, and IP-10 may modify the pathologic features of RRD. The levels of these cytokines are related in part to the clinical features and the level of photoreceptor damage.
通过比较孔源性视网膜脱离（RRD）患者与其他玻璃体视网膜疾病患者的玻璃体液中炎性细胞因子的特征，分析玻璃体内细胞因子与临床特征之间的相关性。手术时从28只RRD患眼中获取玻璃体液。同样从黄斑裂孔（MH）、视网膜前膜、增殖性糖尿病视网膜病变（PDR）和视网膜静脉阻塞患者中收集玻璃体液作为对照。检测了27种细胞因子。通过将RRD患者的玻璃体内细胞因子特征与其他玻璃体视网膜疾病患者的进行比较来进行表征。我们还分析了玻璃体细胞因子与临床特征之间的相关性。RRD与MH患者的MCP-1、MIP-1和IP-10存在统计学差异，而IL-6和IL-8的水平介于PDR和MH患者之间。MIP-1与RRD的范围和持续时间均显著相关，而IL-8与RRD的范围显著相关。MCP-1、MIP-1和IP-10可能会改变RRD的病理特征。这些细胞因子的水平部分与临床特征和光感受器损伤程度有关。
