一种针对Vi抗原的小鼠单克隆抗体及其在沙门氏菌血清分型中的应用。
A mouse monoclonal antibody to Vi antigen & its usefulness in the serotyping of Salmonella.
作者信息
Mohan N, Kumar R
出版信息
Indian J Med Res. 1989 Jul;89:229-32.
PMID:2807427
Abstract
Three IgM monoclonal antibodies (MoAb) designated as MK2, MK3 and MK5 and specific for the Vi antigen of Salmonella typhi have been produced. These antibodies recognise the epitope involving the O-acetyl group of Vi antigen. In slide agglutination tests, these MoAb's agglutinated all 11 isolates of S. typhi but not the other Gram negative bacteria. This selective reactivity makes them better reagents for the identification of S. typhi than the conventional polyclonal antiserum.
摘要
已制备出三种针对伤寒沙门氏菌Vi抗原的IgM单克隆抗体（MoAb），分别命名为MK2、MK3和MK5。这些抗体识别涉及Vi抗原O-乙酰基的表位。在玻片凝集试验中，这些单克隆抗体凝集了所有11株伤寒沙门氏菌分离株，但未凝集其他革兰氏阴性菌。这种选择性反应使它们成为比传统多克隆抗血清更好的伤寒沙门氏菌鉴定试剂。
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