Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, State Key Laboratory of Diagnostic and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Zhejiang University School of Medicine, Hangzhou 310058, China.
Sci Rep. 2017 Jan 11;7:40530. doi: 10.1038/srep40530.
This study aimed to investigate the less known activation pattern of T lymphocyte populations and immune checkpoint inhibitors on immunocytes in patients with bipolar II disorder depression (BD) or major depression (MD). A total of 23 patients with BD, 22 patients with MD, and 20 healthy controls (HCs) were recruited. The blood cell count of T lymphocyte subsets and the plasma level of cytokines (IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ) were selectively investigated. The expression of T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), programmed cell death protein 1 (PD-1) and its ligands, PD-L1 and PD-L2, on T lymphocytes and monocytes, was detected. In results, blood proportion of cytotoxic T cells significantly decreased in BD patients than in either MD patients or HCs. The plasma level of IL-6 increased in patients with BD and MD. The expression of TIM-3 on cytotoxic T cells significantly increased, whereas the expression of PD-L2 on monocytes significantly decreased in patients with BD than in HCs. These findings extended our knowledge of the immune dysfunction in patients with affective disorders.
本研究旨在探讨 T 淋巴细胞群体和免疫检查点抑制剂在双相情感障碍抑郁（BD）或重性抑郁（MD）患者免疫细胞中的激活模式。共招募了 23 名 BD 患者、22 名 MD 患者和 20 名健康对照者（HCs）。选择性研究 T 淋巴细胞亚群的血细胞计数和细胞因子（IL-2、IL-4、IL-6、IL-10、TNF-α和 IFN-γ）的血浆水平。检测 T 淋巴细胞和单核细胞上 T 细胞免疫球蛋白和粘蛋白结构域 3（TIM-3）、程序性细胞死亡蛋白 1（PD-1）及其配体 PD-L1 和 PD-L2 的表达。结果显示，BD 患者的细胞毒性 T 细胞血液比例明显低于 MD 患者或 HCs。BD 和 MD 患者的血浆 IL-6 水平升高。BD 患者的细胞毒性 T 细胞上 TIM-3 的表达显著增加，而单核细胞上 PD-L2 的表达显著低于 HCs。这些发现扩展了我们对情感障碍患者免疫功能障碍的认识。
