Ramezani Mahin, Hatamipour Mahdi, Sahebkar Amirhosein
Nanotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Biotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
J Cell Physiol. 2018 Feb;233(2):880-887. doi: 10.1002/jcp.25795. Epub 2017 May 16.
Curcuminoids are turmeric-extracted phytochemicals with documented chemopreventive and anti-tumor activities against several types of malignancies. Curcuminoids can modulate several molecular pathways and cellular targets involved in different stages of tumor initiation, growth, and metastasis. Bisdemethoxycurcumin (BDMC) is a minor constituent (approximately 3%) of curcuminoids that has been shown to be more stable than the other two main curcuminoids, that is, curcumin and demthoxycurcumin. Recent studies have revealed that BDMC has anti-tumor effects exerted through a multimechanistic mode of action involving inhibition of cell proliferation, invasion and migration, metastasis and tumour growth, and induction of apoptotic death in cancer cells. The present review discusses the findings on the anti-tumor effects of BDMC, underlying mechanisms, and the relevance of finding for translational studies in human.
姜黄素类化合物是从姜黄中提取的植物化学物质，已证明对多种恶性肿瘤具有化学预防和抗肿瘤活性。姜黄素类化合物可以调节参与肿瘤起始、生长和转移不同阶段的多种分子途径和细胞靶点。双去甲氧基姜黄素（BDMC）是姜黄素类化合物中的一种次要成分（约3%），已证明其比其他两种主要的姜黄素类化合物，即姜黄素和去甲氧基姜黄素更稳定。最近的研究表明，BDMC通过多种作用机制发挥抗肿瘤作用，包括抑制细胞增殖、侵袭和迁移、转移和肿瘤生长，以及诱导癌细胞凋亡死亡。本综述讨论了BDMC抗肿瘤作用的研究结果、潜在机制以及这些发现对人类转化研究的相关性。
