Chemical Injuries Research Center, Systems Biology and Poisonings Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran.
School of Biomedical Sciences & Curtin Health Innovation Research Institute, Curtin University, Perth, Australia.
Curr Vasc Pharmacol. 2019;17(3):262-269. doi: 10.2174/1570161116666180209113014.
Curcumin is a naturally occurring polyphenol isolated from Curcuma longa that has various pharmacological activities, including, anti-inflammatory, anti-oxidant and anti-cancer properties. The anticancer effect of curcumin is attributed to activation of apoptotic pathways in cancer cells, as well as inhibition of inflammation and angiogenesis in the tumour microenvironment and suppression of tumour metastasis. Angiogenesis, which is the formation of new blood vessels from pre-existing ones, is a fundamental step in tumour growth and expansion. Several reports have demonstrated that curcumin inhibits angiogenesis in a wide variety of tumour cells through the modulation of various cell signaling pathways which involve transcription factors, protein kinases, growth factors and enzymes. This review provides an updated summary of the various pathways and molecular targets that are regulated by curcumin to elicit its anti-angiogenic activity.
姜黄素是一种从姜黄中分离得到的天然多酚，具有多种药理活性，包括抗炎、抗氧化和抗癌特性。姜黄素的抗癌作用归因于激活癌细胞中的凋亡途径，以及抑制肿瘤微环境中的炎症和血管生成，并抑制肿瘤转移。血管生成是指从现有血管中形成新血管，是肿瘤生长和扩张的基本步骤。有几项报道表明，姜黄素通过调节涉及转录因子、蛋白激酶、生长因子和酶等各种细胞信号通路，抑制多种肿瘤细胞中的血管生成。本文综述了姜黄素调节的各种通路和分子靶点，以发挥其抗血管生成活性。
