Kalaycıoğlu Zeynep, Gazioğlu Işıl, Erim F Bedia
a Department of Chemistry , Istanbul Technical University , Istanbul , Turkey.
b Faculty of Pharmacy, Department of Analytical Chemistry , Bezmialem Vakıf University , Istanbul , Turkey.
Nat Prod Res. 2017 Dec;31(24):2914-2917. doi: 10.1080/14786419.2017.1299727. Epub 2017 Mar 13.
Antioxidant, anticholinesterase and antidiabetic activities of three curcuminoids isolated from the Curcuma longa were simultaneously tested and compared in this study. The highest antioxidant power was detected for curcumin with the applied methods. The drug potentials of curcuminoids for Alzheimer's disease were controlled. Bisdemethoxycurcumin (BDMC) showed substantial inhibitory activity. The activity of demethoxycurcumin (DMC) followed BDMC, whereas curcumin showed very little acetylcholinesterase inhibition activity. Antidiabetic activity of curcuminoids was evaluated by their α-glucosidase inhibitory activities. All curcuminoids show activities with decreasing order as BDMC > curcumin > DMC. The significant activities of BDMC compared to its isomers and examination of chemical structures of isomers might be a starting point in designing new drugs for Alzheimer's and Diabetes Mellitus.
本研究同时测试并比较了从姜黄中分离出的三种姜黄素类化合物的抗氧化、抗胆碱酯酶和抗糖尿病活性。在所应用的方法中，姜黄素的抗氧化能力最强。对姜黄素类化合物治疗阿尔茨海默病的药物潜力进行了评估。双去甲氧基姜黄素（BDMC）表现出显著的抑制活性。去甲氧基姜黄素（DMC）的活性仅次于BDMC，而姜黄素的乙酰胆碱酯酶抑制活性非常低。通过α-葡萄糖苷酶抑制活性评估了姜黄素类化合物的抗糖尿病活性。所有姜黄素类化合物的活性顺序为BDMC＞姜黄素＞DMC。与异构体相比，BDMC的显著活性以及对异构体化学结构的研究可能是设计治疗阿尔茨海默病和糖尿病新药的起点。
